Matches in SemOpenAlex for { <https://semopenalex.org/work/W2182826466> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2182826466 endingPage "1551" @default.
- W2182826466 startingPage "1542" @default.
- W2182826466 abstract "Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism and is found predominantly in adipose tissue and muscle. We examined the mechanism of regulation of LPL in muscles composed of different fiber types (soleus, extensor digitorum longus, and heart) in fed, fasted, and hypothyroid rats. In all muscles, the detergent-extractable (EXT) fraction represented approximately 95% of total LPL activity and mass. LPL activity was similar in the heparin-releasable (HR) fractions of heart and soleus (predominantly type I fibers), while in the EXT fraction LPL activity in soleus was 418 +/- 48 nEq/min per g, and in heart was 272 +/- 30 nEq/min per g (P < 0.05). However, LPL activity in extensor digitorum longus (EDL, predominantly type II fibers) was considerably lower (7.9 +/- 0.8 nEq/min per g in EXT, P < 0.0001 versus heart and soleus). LPL immunoreactive mass followed a pattern similar to LPL activity. LPL mRNA levels were quantitated by both Northern blotting and reverse transcriptase-polymerase chain reaction (RT-PCR), and were approximately equal in heart and soleus, and 5-fold lower in EDL. In response to feeding, LPL activity, mass, and mRNA levels in heart were 30% to 50% lower than in fasted rat heart, although feeding had no effect on soleus or EDL. In hypothyroid animals, muscle LPL activity was increased by 3- to 4-fold in the HR (but not EXT) fractions of heart and soleus (P < 0.05), with no change in LPL mass or mRNA. Thus, muscles with oxidative, type I fibers expressed higher levels of LPL mRNA than muscles containing glycolytic, type II fibers.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2182826466 created "2016-06-24" @default.
- W2182826466 creator A5022172781 @default.
- W2182826466 creator A5027749741 @default.
- W2182826466 creator A5049866305 @default.
- W2182826466 creator A5066466081 @default.
- W2182826466 creator A5084812598 @default.
- W2182826466 date "1994-09-01" @default.
- W2182826466 modified "2023-10-18" @default.
- W2182826466 title "Expression of lipoprotein lipase in rat muscle: regulation by feeding and hypothyroidism." @default.
- W2182826466 cites W1503195770 @default.
- W2182826466 cites W1525497997 @default.
- W2182826466 cites W1561680312 @default.
- W2182826466 cites W1967296335 @default.
- W2182826466 cites W1969299547 @default.
- W2182826466 cites W1980076052 @default.
- W2182826466 cites W2020180324 @default.
- W2182826466 cites W2026573916 @default.
- W2182826466 cites W2040850887 @default.
- W2182826466 cites W2044816854 @default.
- W2182826466 cites W2052565118 @default.
- W2182826466 cites W2060962757 @default.
- W2182826466 cites W2088631301 @default.
- W2182826466 cites W2094973447 @default.
- W2182826466 cites W2097069048 @default.
- W2182826466 cites W2103933115 @default.
- W2182826466 cites W2115448294 @default.
- W2182826466 cites W2125999421 @default.
- W2182826466 cites W2140758909 @default.
- W2182826466 cites W2149897099 @default.
- W2182826466 cites W2181316505 @default.
- W2182826466 cites W2228335567 @default.
- W2182826466 cites W2272105567 @default.
- W2182826466 cites W2324498500 @default.
- W2182826466 cites W2335740117 @default.
- W2182826466 cites W2343078807 @default.
- W2182826466 cites W2414687671 @default.
- W2182826466 cites W2418345646 @default.
- W2182826466 cites W2426592979 @default.
- W2182826466 cites W4238030897 @default.
- W2182826466 cites W4251723806 @default.
- W2182826466 cites W4294216491 @default.
- W2182826466 doi "https://doi.org/10.1016/s0022-2275(20)41152-6" @default.
- W2182826466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7806968" @default.
- W2182826466 hasPublicationYear "1994" @default.
- W2182826466 type Work @default.
- W2182826466 sameAs 2182826466 @default.
- W2182826466 citedByCount "38" @default.
- W2182826466 countsByYear W21828264662014 @default.
- W2182826466 countsByYear W21828264662015 @default.
- W2182826466 countsByYear W21828264662019 @default.
- W2182826466 countsByYear W21828264662023 @default.
- W2182826466 crossrefType "journal-article" @default.
- W2182826466 hasAuthorship W2182826466A5022172781 @default.
- W2182826466 hasAuthorship W2182826466A5027749741 @default.
- W2182826466 hasAuthorship W2182826466A5049866305 @default.
- W2182826466 hasAuthorship W2182826466A5066466081 @default.
- W2182826466 hasAuthorship W2182826466A5084812598 @default.
- W2182826466 hasBestOaLocation W21828264661 @default.
- W2182826466 hasConcept C126322002 @default.
- W2182826466 hasConcept C134018914 @default.
- W2182826466 hasConcept C171089720 @default.
- W2182826466 hasConcept C181199279 @default.
- W2182826466 hasConcept C185592680 @default.
- W2182826466 hasConcept C2779697368 @default.
- W2182826466 hasConcept C55493867 @default.
- W2182826466 hasConcept C71924100 @default.
- W2182826466 hasConcept C86803240 @default.
- W2182826466 hasConcept C94879076 @default.
- W2182826466 hasConceptScore W2182826466C126322002 @default.
- W2182826466 hasConceptScore W2182826466C134018914 @default.
- W2182826466 hasConceptScore W2182826466C171089720 @default.
- W2182826466 hasConceptScore W2182826466C181199279 @default.
- W2182826466 hasConceptScore W2182826466C185592680 @default.
- W2182826466 hasConceptScore W2182826466C2779697368 @default.
- W2182826466 hasConceptScore W2182826466C55493867 @default.
- W2182826466 hasConceptScore W2182826466C71924100 @default.
- W2182826466 hasConceptScore W2182826466C86803240 @default.
- W2182826466 hasConceptScore W2182826466C94879076 @default.
- W2182826466 hasIssue "9" @default.
- W2182826466 hasLocation W21828264661 @default.
- W2182826466 hasOpenAccess W2182826466 @default.
- W2182826466 hasPrimaryLocation W21828264661 @default.
- W2182826466 hasRelatedWork W1966504330 @default.
- W2182826466 hasRelatedWork W1966775726 @default.
- W2182826466 hasRelatedWork W1979139803 @default.
- W2182826466 hasRelatedWork W1991560548 @default.
- W2182826466 hasRelatedWork W2030889776 @default.
- W2182826466 hasRelatedWork W2037631372 @default.
- W2182826466 hasRelatedWork W2040058909 @default.
- W2182826466 hasRelatedWork W2132898409 @default.
- W2182826466 hasRelatedWork W3030938700 @default.
- W2182826466 hasRelatedWork W4249176446 @default.
- W2182826466 hasVolume "35" @default.
- W2182826466 isParatext "false" @default.
- W2182826466 isRetracted "false" @default.
- W2182826466 magId "2182826466" @default.
- W2182826466 workType "article" @default.