Matches in SemOpenAlex for { <https://semopenalex.org/work/W2182835963> ?p ?o ?g. }
- W2182835963 endingPage "68" @default.
- W2182835963 startingPage "56" @default.
- W2182835963 abstract "Liposomes are one of the most widely investigated carriers for siRNA delivery. The surface properties of liposomal carriers, including the surface charge, PEGylation, and ligand modification can significantly affect the gene silencing efficiency. Three barriers of systemic siRNA delivery (long blood circulation, efficient tumor penetration and efficient cellular uptake/endosomal escape) are analyzed on liposomal carriers with different surface charges, PEGylations and ligand modifications. Cationic formulations dominate siRNA delivery and neutral formulations also have good performance while anionic formulations are generally not proper for siRNA delivery. The PEG dilemma (prolonged blood circulation vs. reduced cellular uptake/endosomal escape) and the side effect of repeated PEGylated formulation (accelerated blood clearance) were discussed. Effects of ligand modification on cationic and neutral formulations were analyzed. Finally, we summarized the achievements in liposomal siRNA delivery, outlined existing problems and provided some future perspectives." @default.
- W2182835963 created "2016-06-24" @default.
- W2182835963 creator A5018249388 @default.
- W2182835963 creator A5044701730 @default.
- W2182835963 creator A5069147685 @default.
- W2182835963 date "2016-02-01" @default.
- W2182835963 modified "2023-10-04" @default.
- W2182835963 title "Effect of surface properties on liposomal siRNA delivery" @default.
- W2182835963 cites W1511669342 @default.
- W2182835963 cites W1512179335 @default.
- W2182835963 cites W1585705786 @default.
- W2182835963 cites W1594235507 @default.
- W2182835963 cites W1647075334 @default.
- W2182835963 cites W1796518311 @default.
- W2182835963 cites W1963675633 @default.
- W2182835963 cites W1966461436 @default.
- W2182835963 cites W1972461780 @default.
- W2182835963 cites W1975833492 @default.
- W2182835963 cites W1976811878 @default.
- W2182835963 cites W1979993551 @default.
- W2182835963 cites W1984111387 @default.
- W2182835963 cites W1987259801 @default.
- W2182835963 cites W1995101353 @default.
- W2182835963 cites W1995220749 @default.
- W2182835963 cites W1995770815 @default.
- W2182835963 cites W1996243336 @default.
- W2182835963 cites W2000071382 @default.
- W2182835963 cites W2001583023 @default.
- W2182835963 cites W2001799900 @default.
- W2182835963 cites W2002050544 @default.
- W2182835963 cites W2002721997 @default.
- W2182835963 cites W2007445917 @default.
- W2182835963 cites W2008718396 @default.
- W2182835963 cites W2011962754 @default.
- W2182835963 cites W2012883686 @default.
- W2182835963 cites W2015202374 @default.
- W2182835963 cites W2015530052 @default.
- W2182835963 cites W2016190851 @default.
- W2182835963 cites W2016993123 @default.
- W2182835963 cites W2017048672 @default.
- W2182835963 cites W2017805304 @default.
- W2182835963 cites W2019019265 @default.
- W2182835963 cites W2023878324 @default.
- W2182835963 cites W2024102779 @default.
- W2182835963 cites W2024182029 @default.
- W2182835963 cites W2026250154 @default.
- W2182835963 cites W2032288259 @default.
- W2182835963 cites W2032505506 @default.
- W2182835963 cites W2045029341 @default.
- W2182835963 cites W2045110119 @default.
- W2182835963 cites W2045697805 @default.
- W2182835963 cites W2048497409 @default.
- W2182835963 cites W2051641559 @default.
- W2182835963 cites W2052312685 @default.
- W2182835963 cites W2052382519 @default.
- W2182835963 cites W2053274723 @default.
- W2182835963 cites W2053515735 @default.
- W2182835963 cites W2054797309 @default.
- W2182835963 cites W2054847598 @default.
- W2182835963 cites W2056028296 @default.
- W2182835963 cites W2056493684 @default.
- W2182835963 cites W2057673475 @default.
- W2182835963 cites W2058333505 @default.
- W2182835963 cites W2059201273 @default.
- W2182835963 cites W2059723838 @default.
- W2182835963 cites W2060221489 @default.
- W2182835963 cites W2061812894 @default.
- W2182835963 cites W2063871592 @default.
- W2182835963 cites W2064317408 @default.
- W2182835963 cites W2074399798 @default.
- W2182835963 cites W2079491964 @default.
- W2182835963 cites W2080356693 @default.
- W2182835963 cites W2081290297 @default.
- W2182835963 cites W2082556053 @default.
- W2182835963 cites W2083249633 @default.
- W2182835963 cites W2083862691 @default.
- W2182835963 cites W2086393160 @default.
- W2182835963 cites W2087339674 @default.
- W2182835963 cites W2089150369 @default.
- W2182835963 cites W2091395844 @default.
- W2182835963 cites W2092738402 @default.
- W2182835963 cites W2100831675 @default.
- W2182835963 cites W2110083155 @default.
- W2182835963 cites W2111436238 @default.
- W2182835963 cites W2112932690 @default.
- W2182835963 cites W2113693222 @default.
- W2182835963 cites W2118561606 @default.
- W2182835963 cites W2120085804 @default.
- W2182835963 cites W2120820989 @default.
- W2182835963 cites W2121125746 @default.
- W2182835963 cites W2123585553 @default.
- W2182835963 cites W2125301080 @default.
- W2182835963 cites W2125460615 @default.
- W2182835963 cites W2129825215 @default.
- W2182835963 cites W2134444723 @default.
- W2182835963 cites W2137287870 @default.
- W2182835963 cites W2141540858 @default.
- W2182835963 cites W2147010494 @default.