FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2182868217> ?p ?o ?g. }

• W2182868217 abstract "Introduction: Altered pharmacokinetics (PK) in critically ill patients can result in insufficient serum β-lactam concentrations when standard dosages are administered. Previous studies on β-lactam PK have generally excluded the most severely ill patients, or were conducted during the steady-state period of treatment. The aim of our study was to determine whether the first dose of piperacillin-tazobactam, ceftazidime, cefepime, and meropenem would result in adequate serum drug concentrations in patients with severe sepsis and septic shock. Methods: Open, prospective, multicenter study in four Belgian intensive care units. All consecutive patients with a diagnosis of severe sepsis or septic shock, in whom treatment with the study drugs was indicated, were included. Serum concentrations of the antibiotics were determined by high-pressure liquid chromatography (HPLC) before and 1, 1.5, 4.5 and 6 or 8 hours after administration. Results: 80 patients were treated with piperacillin-tazobactam (n = 27), ceftazidime (n = 18), cefepime (n = 19) or meropenem (n = 16). Serum concentrations remained above 4 times the minimal inhibitory concentration (T > 4 × MIC), corresponding to the clinical breakpoint for Pseudomonas aeruginosa defined by the European Committee on Antimicrobial Susceptibility Testing (EUCAST), for 57% of the dosage interval for meropenem (target MIC = 8 μg/mL), 45% for ceftazidime (MIC = 32 μg/mL), 34% for cefepime (MIC = 32 μg/mL), and 33% for piperacillin-tazobactam (MIC = 64 μg/mL). The number of patients who attained the target PK profile was 12/16 for meropenem (75%), 5/18 for ceftazidime (28%), 3/19 (16%) for cefepime, and 12/27 (44%) for piperacillin-tazobactam. Conclusions: Serum concentrations of the antibiotic after the first dose were acceptable only for meropenem. Standard dosage regimens for piperacillin-tazobactam, ceftazidime and cefepime may, therefore, be insufficient to empirically cover less susceptible pathogens in the early phase of severe sepsis and septic shock." @default.
• W2182868217 created "2016-06-24" @default.
• W2182868217 creator A5010850499 @default.
• W2182868217 creator A5043353678 @default.
• W2182868217 creator A5043482559 @default.
• W2182868217 creator A5047676849 @default.
• W2182868217 creator A5050393463 @default.
• W2182868217 creator A5051817687 @default.
• W2182868217 creator A5057748388 @default.
• W2182868217 creator A5059608367 @default.
• W2182868217 creator A5071009539 @default.
• W2182868217 creator A5086098730 @default.
• W2182868217 creator A5086479154 @default.
• W2182868217 date "2010-01-01" @default.
• W2182868217 modified "2023-09-24" @default.
• W2182868217 title "Researchβ-lactam concentrations in the early phase of severe sepsis and septic shock" @default.
• W2182868217 cites W1538914313 @default.
• W2182868217 cites W1550111394 @default.
• W2182868217 cites W1603963832 @default.
• W2182868217 cites W1696021819 @default.
• W2182868217 cites W1898928487 @default.
• W2182868217 cites W1964308581 @default.
• W2182868217 cites W1982143055 @default.
• W2182868217 cites W1984026433 @default.
• W2182868217 cites W2007818273 @default.
• W2182868217 cites W2009989026 @default.
• W2182868217 cites W2015720649 @default.
• W2182868217 cites W2016888150 @default.
• W2182868217 cites W2025335830 @default.
• W2182868217 cites W2027169933 @default.
• W2182868217 cites W2029534800 @default.
• W2182868217 cites W2032781000 @default.
• W2182868217 cites W2052818550 @default.
• W2182868217 cites W2054938569 @default.
• W2182868217 cites W2057226149 @default.
• W2182868217 cites W2057650704 @default.
• W2182868217 cites W2065177826 @default.
• W2182868217 cites W2066890756 @default.
• W2182868217 cites W2069282801 @default.
• W2182868217 cites W2079691262 @default.
• W2182868217 cites W2082321986 @default.
• W2182868217 cites W2087203965 @default.
• W2182868217 cites W2090598659 @default.
• W2182868217 cites W2093814712 @default.
• W2182868217 cites W2100510403 @default.
• W2182868217 cites W2106729847 @default.
• W2182868217 cites W2107093554 @default.
• W2182868217 cites W2112790784 @default.
• W2182868217 cites W2118858814 @default.
• W2182868217 cites W2118905287 @default.
• W2182868217 cites W2122724068 @default.
• W2182868217 cites W2129085875 @default.
• W2182868217 cites W2130793449 @default.
• W2182868217 cites W2131171455 @default.
• W2182868217 cites W2136028041 @default.
• W2182868217 cites W2141061750 @default.
• W2182868217 cites W2141173497 @default.
• W2182868217 cites W2142365884 @default.
• W2182868217 cites W2143024482 @default.
• W2182868217 cites W2143150107 @default.
• W2182868217 cites W2144126572 @default.
• W2182868217 cites W2148706534 @default.
• W2182868217 cites W2149026959 @default.
• W2182868217 cites W2158308518 @default.
• W2182868217 cites W2161994258 @default.
• W2182868217 cites W95902431 @default.
• W2182868217 cites W2107978811 @default.
• W2182868217 hasPublicationYear "2010" @default.
• W2182868217 type Work @default.
• W2182868217 sameAs 2182868217 @default.
• W2182868217 citedByCount "0" @default.
• W2182868217 crossrefType "journal-article" @default.
• W2182868217 hasAuthorship W2182868217A5010850499 @default.
• W2182868217 hasAuthorship W2182868217A5043353678 @default.
• W2182868217 hasAuthorship W2182868217A5043482559 @default.
• W2182868217 hasAuthorship W2182868217A5047676849 @default.
• W2182868217 hasAuthorship W2182868217A5050393463 @default.
• W2182868217 hasAuthorship W2182868217A5051817687 @default.
• W2182868217 hasAuthorship W2182868217A5057748388 @default.
• W2182868217 hasAuthorship W2182868217A5059608367 @default.
• W2182868217 hasAuthorship W2182868217A5071009539 @default.
• W2182868217 hasAuthorship W2182868217A5086098730 @default.
• W2182868217 hasAuthorship W2182868217A5086479154 @default.
• W2182868217 hasConcept C112705442 @default.
• W2182868217 hasConcept C126322002 @default.
• W2182868217 hasConcept C177713679 @default.
• W2182868217 hasConcept C2776968632 @default.
• W2182868217 hasConcept C2777050379 @default.
• W2182868217 hasConcept C2777628635 @default.
• W2182868217 hasConcept C2777637488 @default.
• W2182868217 hasConcept C2777858937 @default.
• W2182868217 hasConcept C2778193466 @default.
• W2182868217 hasConcept C2778266534 @default.
• W2182868217 hasConcept C2778384902 @default.
• W2182868217 hasConcept C2779375183 @default.
• W2182868217 hasConcept C2987404301 @default.
• W2182868217 hasConcept C42219234 @default.
• W2182868217 hasConcept C501593827 @default.
• W2182868217 hasConcept C523546767 @default.
• W2182868217 hasConcept C54355233 @default.

• next