Matches in SemOpenAlex for { <https://semopenalex.org/work/W2182879529> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2182879529 abstract "Gastroretentive systems can remain in the gastric region for several hours and hence significantly prolong the gastric residence time of drugs. The objective of present investigation is to develop pH sensitive extended and controlled release formulation of acetohydroxamic acid loaded oil entrapped calcium pectinate micro gel beads. Pectin based oil entrapped micro gel beads were prepared by ionic gelation technique. The drug was formulated into micro gel bead with entrapping the castor oil or mineral oil . Gel beads were prepared instantly after dropping of the formulation mixture into calcium chloride solutions. The beads were optimized by coating with ethylcellulose solution. The prepared beads were evaluated with diameter, floating lag time and % encapsulation efficiency , % drug content and drug release. The prepared beads were spherical and were found high drug content and encapsulation efficiency. The formulation exhibited sustained release behaviour and was best fitted in the Peppas model with n < 0.45. Subsequent coating of the selected batch of microbeads exhibited zero-order sustained pattern of the drug release up to 8 hr. The goodness of fitting the release data to the model was indicated by high correlation coefficient value and small errors. The optimized batch was found to be higher gastric retention efficiency in the albino rats and eradication efficiency for isolated Helicobacter pylori (H. pylori ) strain . The results indicate that the prepared optimize bead was promising for the maintenance of effective concentration of the drug in the vicinity of H. pylori infection and was effective in term of complete termination of the infection from the stomach.." @default.
- W2182879529 created "2016-06-24" @default.
- W2182879529 creator A5012506041 @default.
- W2182879529 creator A5042102328 @default.
- W2182879529 creator A5061876144 @default.
- W2182879529 date "2011-01-01" @default.
- W2182879529 modified "2023-09-22" @default.
- W2182879529 title "Evaluation of pH trigger oil entrapped buoyant beads of acetohydroxamic acid for eradication of Helicobacter pylori" @default.
- W2182879529 cites W1588335714 @default.
- W2182879529 cites W1968798448 @default.
- W2182879529 cites W1974558951 @default.
- W2182879529 cites W1977072597 @default.
- W2182879529 cites W1987743435 @default.
- W2182879529 cites W1988593099 @default.
- W2182879529 cites W2004642933 @default.
- W2182879529 cites W2009343072 @default.
- W2182879529 cites W2022948175 @default.
- W2182879529 cites W2086130473 @default.
- W2182879529 cites W2087544226 @default.
- W2182879529 cites W2091668211 @default.
- W2182879529 cites W2097410681 @default.
- W2182879529 cites W2098000490 @default.
- W2182879529 cites W2102374831 @default.
- W2182879529 cites W2104099221 @default.
- W2182879529 cites W82569690 @default.
- W2182879529 hasPublicationYear "2011" @default.
- W2182879529 type Work @default.
- W2182879529 sameAs 2182879529 @default.
- W2182879529 citedByCount "0" @default.
- W2182879529 crossrefType "journal-article" @default.
- W2182879529 hasAuthorship W2182879529A5012506041 @default.
- W2182879529 hasAuthorship W2182879529A5042102328 @default.
- W2182879529 hasAuthorship W2182879529A5061876144 @default.
- W2182879529 hasConcept C126322002 @default.
- W2182879529 hasConcept C178790620 @default.
- W2182879529 hasConcept C181199279 @default.
- W2182879529 hasConcept C185592680 @default.
- W2182879529 hasConcept C2776409635 @default.
- W2182879529 hasConcept C2778713300 @default.
- W2182879529 hasConcept C2779521917 @default.
- W2182879529 hasConcept C2780035454 @default.
- W2182879529 hasConcept C2781421780 @default.
- W2182879529 hasConcept C2781448156 @default.
- W2182879529 hasConcept C2908868296 @default.
- W2182879529 hasConcept C43617362 @default.
- W2182879529 hasConcept C519063684 @default.
- W2182879529 hasConcept C55493867 @default.
- W2182879529 hasConcept C71924100 @default.
- W2182879529 hasConcept C77281830 @default.
- W2182879529 hasConcept C98274493 @default.
- W2182879529 hasConceptScore W2182879529C126322002 @default.
- W2182879529 hasConceptScore W2182879529C178790620 @default.
- W2182879529 hasConceptScore W2182879529C181199279 @default.
- W2182879529 hasConceptScore W2182879529C185592680 @default.
- W2182879529 hasConceptScore W2182879529C2776409635 @default.
- W2182879529 hasConceptScore W2182879529C2778713300 @default.
- W2182879529 hasConceptScore W2182879529C2779521917 @default.
- W2182879529 hasConceptScore W2182879529C2780035454 @default.
- W2182879529 hasConceptScore W2182879529C2781421780 @default.
- W2182879529 hasConceptScore W2182879529C2781448156 @default.
- W2182879529 hasConceptScore W2182879529C2908868296 @default.
- W2182879529 hasConceptScore W2182879529C43617362 @default.
- W2182879529 hasConceptScore W2182879529C519063684 @default.
- W2182879529 hasConceptScore W2182879529C55493867 @default.
- W2182879529 hasConceptScore W2182879529C71924100 @default.
- W2182879529 hasConceptScore W2182879529C77281830 @default.
- W2182879529 hasConceptScore W2182879529C98274493 @default.
- W2182879529 hasLocation W21828795291 @default.
- W2182879529 hasOpenAccess W2182879529 @default.
- W2182879529 hasPrimaryLocation W21828795291 @default.
- W2182879529 hasRelatedWork W1599565322 @default.
- W2182879529 hasRelatedWork W2030507956 @default.
- W2182879529 hasRelatedWork W2052094244 @default.
- W2182879529 hasRelatedWork W2123010608 @default.
- W2182879529 hasRelatedWork W2130650061 @default.
- W2182879529 hasRelatedWork W2131279941 @default.
- W2182879529 hasRelatedWork W2189464184 @default.
- W2182879529 hasRelatedWork W2347919091 @default.
- W2182879529 hasRelatedWork W2367081782 @default.
- W2182879529 hasRelatedWork W2413478500 @default.
- W2182879529 hasRelatedWork W2440634081 @default.
- W2182879529 hasRelatedWork W2546956424 @default.
- W2182879529 hasRelatedWork W2584593704 @default.
- W2182879529 hasRelatedWork W2586717977 @default.
- W2182879529 hasRelatedWork W2591925330 @default.
- W2182879529 hasRelatedWork W2735833928 @default.
- W2182879529 hasRelatedWork W2185039772 @default.
- W2182879529 hasRelatedWork W2188139862 @default.
- W2182879529 hasRelatedWork W2189293172 @default.
- W2182879529 hasRelatedWork W2337133371 @default.
- W2182879529 isParatext "false" @default.
- W2182879529 isRetracted "false" @default.
- W2182879529 magId "2182879529" @default.
- W2182879529 workType "article" @default.