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- W2182923592 abstract "Azithromycin is an azalide antimicrobial commonly used in human medicine. Azalides are similar to macrolides in that they both inhibit bacterial protein synthesis by binding to subunits of the 50S ribosome. Like erythromycin, azithromycin is mainly effective against Gram-positive aerobes. Studies in other species have shown that azithromycin has improved pharmacokinetics, is safer, and is slightly more effective against gram-negative and anaerobic bacteria when compared to erythromycin. The use of erythromycin in foals for the treatment of Rhodococcus equi pneumonia has been associated with several complications. Furthermore, erythromycin has an inconsistent absorption in foals when given orally and a growing number of resistant R. equi isolates have been identified. Because of its numerous advantages over erythromycin, azithromycin is an attractive alternative for the treatment of R. equi infections. The purpose of this study was to investigate the pharmacokinetics of azithromycin in foals and to determine its bioavailability and concentrations in serum, body fluids, and bronchoalveolar cells after repeated intragastric administration. 2. Materials and Methods" @default.
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- W2182923592 date "2001-01-01" @default.
- W2182923592 modified "2023-09-26" @default.
- W2182923592 title "Pharmacokinetics of Azithromycin in Foals" @default.
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