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• W2182923942 abstract "Hepatocellular carcinoma (HCC) is among the fifth most common cancers worlwide. The geographic areas at higher risk are located in China and eastern Asia, middle Africa and some countries of western Africa. Lower incidences are encountered in Japan, Europe and America, but this incidence is still rising in part because of the high level of hepatitis C virus infection. The preponderance in males is universal and HCC is the commonest in subjects over the age of 40, although it can be observed in younger. The prognosis is generally poor, especially in Africans and Chinese where survival time may be as short as 11 weeks from the onset of symptoms. The causes of more than 85% of HCC cases are known (hepatitis B and C, aflatoxin B1, ethanol, metabolic diseases). HCC is an epithelial tumor developing from hepatocytes. In the majority of cases, cirrhosis is the major underlying risk factor, but HCC may occur also on chronic hepatitis or normal liver. Mechanisms of hepatocarcinogenesis are not completely understood but, like most solid tumors, the development and progression of HCC are believed to be caused by the accumulation of genetic changes resulting in altered expression of cancer-related genes, such as oncogenes or tumor suppressor genes, as well as genes involved in different regulatory pathways. The genetic changes involved can be divided in at least 4 different pathways, each pathway contributing to a limited number of tumors. These are :" @default.
• W2182923942 created "2016-06-24" @default.
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• W2182923942 date "2004-01-01" @default.
• W2182923942 modified "2023-09-24" @default.
• W2182923942 title "Atlas of Genetics and Cytogenetics in Oncology and Haematology" @default.
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