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- W2182939541 abstract "Objective: This study was designed to prepare a gastro-retentive floating tablet of nizatidine in an attempt to prolong its gastric residence time and hence increase its efficacy. Methods: The tablets were prepared by direct compression technique using hydroxypropylmethyl cellulose (HPMC k4M). The effect of different formulation variables including polymer concentration, incorporation of different concentrations of carbopol934 or sodium alginate as release retarding polymers and concentration of an effervescent mixture (sodium bicarbonate and citric acid) on drug release and floating properties was investigated. In addition, the optimized formulation (combined excellent floating behavior and sustained drug release) was compared to conventional nizatidine tablet for antiulcer activity in rabbits. Results: The optimized formulation containing 175 mg HPMC k4M, 25 mg carbopol934 and 50 mg effervescent mixture showed 80% drug release within 10.6 h±0.3, floating lag time of about 5.00±0.2 min and total floating time of >24 hours. In vivo results proved that nizatidine floating tablet had more pronounced antiulcer effect than its conventional tablet. Conclusion: The effervescent based floating tablet of nizatidine could be a promising approach to increase its gastric residence time up to 12 hours, thereby improving its antiulcer efficacy." @default.
- W2182939541 created "2016-06-24" @default.
- W2182939541 creator A5002381786 @default.
- W2182939541 date "2014-01-01" @default.
- W2182939541 modified "2023-09-26" @default.
- W2182939541 title "DESIGN AND EVALUATION OF GASTRORETENTIVE FLOATING TABLET OF NIZATIDINE: A TRIAL TO IMPROVE ITS EFFICACY" @default.
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