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- W2182957790 abstract "Single, preexposure, parenteral uijection withbothrecombinant tumornecrosis factor/cachectin (TNF/C) andinterleukin-1 (IL1)prolonged thesurvival ofrats(144±9h)incontinuous hyperoxia (>99%02 at1atm)whencompared withratsinjected withboiled TNF/Candboiled IL-1(61±2h),TNF/Calone (61±2h),IL-1alone(62±2h), orsaline (64±3h).Afterexposuretohyperoxia for52h,pleural effusion volume, pulmonary artery pressure, total pulmonary resistance, andlung morphologic damage weredecreased inthose ratsgiven TNF/CandIL-1 as compared withsaline-injected rats. Inparallel, ratios ofreduced (GSH)tooxidized (GSSG)glutathione weregreater (P< 005) inlungs ofTNF/C+IL-i-injected rats(91±20) thanofsalineinjected rats(30±4) thathadbeenexposed tohyperoxia for52 h.Nodifferences werefound insuperoxide dismutase, glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase, orcatalase activities inlungs ofTNF/C+ IL-1- or saline-treated, hyperoxia-exposed rats. Ourresults indicate that pretreatment withTNF/CandIL-1favorably altered lungglutathione redoxstatus, decreased lung injury, andenhanced survival ofratsexposed tohyperoxia." @default.
- W2182957790 created "2016-06-24" @default.
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- W2182957790 date "1987-01-01" @default.
- W2182957790 modified "2023-09-24" @default.
- W2182957790 title "Recombinant TumorNecrosis Factor/Cachectin andInterleukin 1Pretreatment Decreases LungOxidized Glutathione Accumulation, LungInjury, andMortality inRatsExposedtoHyperoxia" @default.
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