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- W2182960008 abstract ", but how does insulin resistancegradually result in the disease? Does insulinsecretory function simply decrease with age?The concepts of “glucotoxicity” and “lipo-toxicity” have been advanced to explain thepathogenesis of T2DM. More recently it hasbeen proposed that adipokines, i.e., hor-mones secreted by the adipose tissue, can im-pair glucose tolerance. In this editorial I triedto highlight some recent developments in theunderstanding of the pathophysiological linksbetween obesity and T2DM in humans." @default.
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- W2182960008 date "2003-04-24" @default.
- W2182960008 modified "2023-09-23" @default.
- W2182960008 title "Pathophysiology of obesity-induced insulin resistance and type 2 diabetes mellitus." @default.
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