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• W2182960595 startingPage "941" @default.
• W2182960595 abstract "GIP (glucose dependent insulinotrophic polypeptide), originally identified as an incretin peptide synthesized in the gut, has recently been identified, along with its receptors (GIPR), in the brain. Our objective was to investigate the role of GIP in hypothalamic gene expression of biomarkers linked to regulating energy balance and feeding behavior related neurocircuitry. Rats with lateral cerebroventricular cannulas were administered 10 μg GIP or 10 microl artificial cerebrospinal fluid (aCSF) daily for 4 days, after which whole hypothalami were collected. Real time Taqman™ RT-PCR was used to quantitatively compare the mRNA expression levels of a set of genes in the hypothalamus. Administration of GIP resulted in up-regulation of hypothalamic mRNA levels of AVP (46.9±4.5 %), CART (25.9±2.7 %), CREB1 (38.5±4.5 %), GABRD (67.1±11 %), JAK2 (22.1±3.6 %), MAPK1 (33.8±7.8 %), NPY (25.3±5.3 %), OXT (49.1±5.1 %), STAT3 (21.6±3.8 %), and TH (33.9±8.5 %). In a second experiment the same set of genes was evaluated in GIPR(-/-) and GIPR(+/?) mice to determine the effect of lack of GIP stimulation on gene expression. In GIPR(-/-) mice expressions of the following genes were down-regulated: AVP (27.1±7.5 %), CART (28.3±3.7 %), OXT (25.2±5.8 %), PTGES (23.9±4.5 %), and STAT3 (8.8±2.3 %). These results suggest that AVP, CART, OXT and STAT3 may be involved in energy balance-related hypothalamic circuits affected by GIP." @default.
• W2182960595 created "2016-06-24" @default.
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• W2182960595 date "2011-12-16" @default.
• W2182960595 modified "2023-10-11" @default.
• W2182960595 title "GIP-Dependent Expression of Hypothalamic Genes" @default.
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• W2182960595 cites W1529247698 @default.
• W2182960595 cites W1900852307 @default.
• W2182960595 cites W1948173875 @default.
• W2182960595 cites W1970049843 @default.
• W2182960595 cites W1976646759 @default.
• W2182960595 cites W1977097317 @default.
• W2182960595 cites W1977915489 @default.
• W2182960595 cites W1979707798 @default.
• W2182960595 cites W1983082230 @default.
• W2182960595 cites W1985154343 @default.
• W2182960595 cites W1986930544 @default.
• W2182960595 cites W1991798879 @default.
• W2182960595 cites W1991975247 @default.
• W2182960595 cites W1992535385 @default.
• W2182960595 cites W1993181430 @default.
• W2182960595 cites W1997508587 @default.
• W2182960595 cites W1999310003 @default.
• W2182960595 cites W2004507897 @default.
• W2182960595 cites W2007027938 @default.
• W2182960595 cites W2009098875 @default.
• W2182960595 cites W2011588666 @default.
• W2182960595 cites W2012071311 @default.
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• W2182960595 cites W2025078194 @default.
• W2182960595 cites W2026038046 @default.
• W2182960595 cites W2026200282 @default.
• W2182960595 cites W2027012370 @default.
• W2182960595 cites W2029595925 @default.
• W2182960595 cites W2032704413 @default.
• W2182960595 cites W2033825599 @default.
• W2182960595 cites W2041624270 @default.
• W2182960595 cites W2043911925 @default.
• W2182960595 cites W2045413517 @default.
• W2182960595 cites W2046747151 @default.
• W2182960595 cites W2047798798 @default.
• W2182960595 cites W2049864554 @default.
• W2182960595 cites W2053544091 @default.
• W2182960595 cites W2054866617 @default.
• W2182960595 cites W2060082940 @default.
• W2182960595 cites W2062009567 @default.
• W2182960595 cites W2068834629 @default.
• W2182960595 cites W2074835704 @default.
• W2182960595 cites W2078463927 @default.
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• W2182960595 cites W2099544342 @default.
• W2182960595 cites W2102392334 @default.
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• W2182960595 cites W2123030262 @default.
• W2182960595 cites W2128140485 @default.
• W2182960595 cites W2128979121 @default.
• W2182960595 cites W2136803357 @default.
• W2182960595 cites W2136824109 @default.
• W2182960595 cites W2139470767 @default.
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• W2182960595 cites W2167843578 @default.
• W2182960595 cites W2172150005 @default.
• W2182960595 cites W2172238082 @default.
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• W2182960595 doi "https://doi.org/10.33549/physiolres.932151" @default.
• W2182960595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21995902" @default.
• W2182960595 hasPublicationYear "2011" @default.
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