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• W2182994217 abstract "Magnetic nanoparticle-containing capsules have been proposed for many uses, including triggered drug delivery and imaging. Combining superparamagnetic iron oxide nanoparticles (SPIONs) with existing liposome drug delivery technology is an enticing near-future prospect, but it requires efficient methods of synthesis and formulation compatible with pharmaceutical applications. We report a facile way of producing large, unilamellar, and homogeneously sized magnetoliposomes with high content of monodisperse, hydrophobic SPIONs integrated in the lipid membrane by use of a solvent inversion technique. For low lipid concentrations, unilamellar and monodisperse vesicles were obtained that became increasingly multilamellar with higher lipid fraction. Both, the co-self-assembled structure and loading content were significantly influenced by the purity of the nanoparticle shell. SPIONs with homogeneous shells of nitrodopamine-anchored hydrophobic dispersants could be quantitatively loaded up to 20%w/w, while SPIONs also containing residual physisorbed oleic acid exhibited a loading cut-off around 10%w/w SPIONs accompanied by drastic changes in size distribution. Lipid acyl chain length crucially influenced the formation and resultant stability of the loaded assemblies. The formation of nanoparticle-loaded vesicles is exemplified in different biologically important media, yielding ready-to-use magnetoliposome formulations." @default.
• W2182994217 created "2016-06-24" @default.
• W2182994217 creator A5041685218 @default.
• W2182994217 creator A5067095868 @default.
• W2182994217 date "2016-03-01" @default.
• W2182994217 modified "2023-10-14" @default.
• W2182994217 title "Controlled magnetosomes: Embedding of magnetic nanoparticles into membranes of monodisperse lipid vesicles" @default.
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• W2182994217 doi "https://doi.org/10.1016/j.jcis.2015.11.071" @default.
• W2182994217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26707773" @default.
• W2182994217 hasPublicationYear "2016" @default.
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