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• W2182997669 abstract "Summary Teucrium polium (Lamiaceae) is used both as a food to prevent health and as a drug to treat hyperglycemia in Iran. In this study, we isolated the high free radical scavenging and anti0 glycation compounds from T. polium and protective effect of both flavonoid compounds was evaluated on rat isolated islets in streptozotocin induced oxidative stress. Based on our results, rutin (quercetin030rutinoside ) and apigenin isolated from T. polium exhibited high antioxidant activities compared to the other isolated compounds from T. polium. Regarding the link between glycation and oxidation, we proposed that the rutin and apigenin might possess significant in vitro antiglycation activities as well. These two flavonoids also showed strong inhibitory effects on the production of advanced glycation end products (AGEs) from bovine serum albumin in the presence of glucose in term of PCO formation and thiol oxidation. In addition, rutin as well as apigenin able to prevent oxidative stress condition induced by streptozotocin and increase insulin release in rat islets. It may be concluded that T. polium possess potent antiglycation and insulinotropic compounds, which can be of great value in the preventive glycation associated complications in diabetes." @default.
• W2182997669 created "2016-06-24" @default.
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• W2182997669 date "2009-01-01" @default.
• W2182997669 modified "2023-09-26" @default.
• W2182997669 title "Pancreatic BCell Protective Effect of Rutin and Ap igenin Isolated from Teucrium Polium" @default.
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