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- W2183062942 abstract "Background and Objectives: The treatment of patients with functional dyspepsia remains unsatisfactory , though prokinetic drugs are widely used for treatment of functional dyspepsia. We designed a randomized, placebo-controlled to assess the efficacy and safety of a new prokinetic drug itopride hydrochloride, a dopamine D2 antagonist with antiacetylcholinesterase effects, in patients with dysmotility-like functional dyspepsia. Methods: Sixty-seven eligible patients were enrolled and were randomly assigned to receive either itopride 10 mg three times a day or placebo for a period of 4 weeks. Pwere re-assessed at 2 and 4 weeks for improvement in dyspepsiaspecific symptom score (pain/discomfort, fullness, bloating, early satiety, and nausea/vomiting), global symptom score and and the effect on subjective global assessment of relief. Adverse events also were recorded. Results: The symptom scores prior to treatment were comparable in the both groups. After completion of 2-week and 4week treatment, the symptom scores were significantly lower in the itopride group compared to the placebo group (11.2 ± 4.0 vs 15.03±4.2; p = 0.0003) and (9.3±4.1 vs 14.4±5.8; p = 0.0004), respectively . The subjective assessment of global relief was significantly higher in the itopride group (11 of 33patients) compared to 1 of 34 patients in the placebo group. Conclusions: Itopride is superior to placebo in the treatment of functional dyspepsia having bloating and fullness as their predominant symptoms. It can be used safely in this subset of patients where proton pump inhibitors may not be very effective.( J Dig Endos 2010;1(4):171-75)" @default.
- W2183062942 created "2016-06-24" @default.
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- W2183062942 date "2010-01-01" @default.
- W2183062942 modified "2023-09-27" @default.
- W2183062942 title "Itopride in the Treatment of Dysmotility-like Functional Dyspepsia: A Randomized, Placebo-Controlled Trial" @default.
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