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- W2183075003 abstract "Many human diseases appear to affect discrete cell types in very specific ways. The fundamental concept underlying cellular reprogramming is the idea that if it were feasible to reprogram an unaffected cell type to take over the function of the affected cell type this then would facilitate the therapy of a large number of such diseases. In this way, scar fibroblasts might be reprogrammed to become cardiomyocytes after a myocardial infarction or working myocytes might be reprogrammed to become conduction system cells in the setting of nodal or His-Purkinje disease. While until recently, the notion of one cell type being directed to a distinct fate in a regulated manner might have been fanciful, the discovery of methods to reprogram fully differentiated cells like skin fibroblasts to truly pluripotent stem cells has led to a surge of interest in controlled reprogramming to address a wide range of clinical problems. The experimental strategies being explored will not only address the core determinants of cell fate [1], but also the feasibility of early therapeutic applications and even the possibility of definitive regeneration for adult human myocardium." @default.
- W2183075003 created "2016-06-24" @default.
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- W2183075003 date "2016-01-01" @default.
- W2183075003 modified "2023-09-27" @default.
- W2183075003 title "In vitro and in vivo reprogramming for the conduction system" @default.
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- W2183075003 doi "https://doi.org/10.1016/j.tcm.2015.08.005" @default.
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