FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2183076943> ?p ?o ?g. }

• W2183076943 endingPage "54" @default.
• W2183076943 startingPage "235" @default.
• W2183076943 abstract "Human placental trophoblastic mass grows rapidly between 4 and 8 weeks of gestation making it highly vulnerable to external and internal challenges, however, there has been no reported study exploring the developmental molecular characteristics in human first trimester placental villi. In the present study, transcript expressions of human placental villi of normal pregnancies during 6 (n=6), 7 (n=6) and 8 (n=6) weeks of gestation using custom-tailored cDNA-based expression arrays for -400 annotated human gene products were examined. Unsupervised and supervised analyses of expression data revealed that 386 (95%) genes were overtly involved in the first trimester placental villi, and these genes segregated into three clusters specifically corresponding to 6-, 7- and 8-weeks of gestation in principal component analysis. Bayesian prediction analysis based on relative expression levels of genes studied identified that expression patterns in 15 samples out of 18 samples showed concordance with high (0.8-1.0) confidence measures with the chronological age of the placenta, however, two samples collected during 7-weeks of gestation and one sample collected during 8-weeks of gestation were predicted to be 6-weeks sample with confidence measures between 0.6 and 0.5. Unsupervised hierarchical clustering analysis segregated the samples into two major branches; while one of them was composed of five 7-weeks samples only, the second major branch had three sub-branches: one of them was exclusively composed of three 8-week samples only, while other two sub-branches were mainly composed of 6-weeks samples. K-means clustering analysis identified four optimal clusters of genes depending on the similarity of their relative expression for the set of genes studied across all the samples. Gene ontology (GO) based functional classifications of genes in K-means clusters revealed that the overall putative functions of co-regulated gene clusters were mutually comparable, however, specific genes related to ion homeostasis, metabolism, and VEGF activity specifically clustered in 8-weeks samples. Analysis of relative gene expression during in 6-8 week placental villi revealed that a large number of gene products were over represented by their either up-regulation (70 genes: approximately 18%) or down regulation (53 genes; approximately 14%) between 6 and 8 weeks villi samples and these genes are reportedly involved in biological processes like regulation of cell growth and proliferation, anti-apoptosis, angiogenesis, immune and inflammatory responses, extracellular matrix remodeling and multicellular organismal development involving almost all cellular components and molecular functions like signal transduction activity, transcription factor activity, nucleotide and protein binding, ion (especially calcium and zinc) binding and growth receptor activities. Interestingly, four genes (oxytocin receptor, tenascin C, TNF-R1 and retinol binding protein 1) showed differential regulation in human placental villi during 6-8 weeks of gestation, suggestive of an underlying network of regulation involving these factors in the developing placenta. To our knowledge, this is the first report indicating that these genes are involved in the early stage development of human placenta." @default.
• W2183076943 created "2016-06-24" @default.
• W2183076943 creator A5037518774 @default.
• W2183076943 creator A5060266030 @default.
• W2183076943 creator A5070114419 @default.
• W2183076943 creator A5070804361 @default.
• W2183076943 creator A5076238135 @default.
• W2183076943 creator A5078374399 @default.
• W2183076943 creator A5080895200 @default.
• W2183076943 date "2011-03-18" @default.
• W2183076943 modified "2023-09-25" @default.
• W2183076943 title "Small scale transcript expression profile of Human first trimester placental villi analyzed by a custom-tailored cDNA array." @default.
• W2183076943 cites W1596965334 @default.
• W2183076943 cites W1686927379 @default.
• W2183076943 cites W1696199194 @default.
• W2183076943 cites W1726784060 @default.
• W2183076943 cites W1971028875 @default.
• W2183076943 cites W2029194186 @default.
• W2183076943 cites W2029916401 @default.
• W2183076943 cites W2036705392 @default.
• W2183076943 cites W2042136955 @default.
• W2183076943 cites W2042923816 @default.
• W2183076943 cites W2044487543 @default.
• W2183076943 cites W2049611684 @default.
• W2183076943 cites W2078775644 @default.
• W2183076943 cites W2079947201 @default.
• W2183076943 cites W2080040490 @default.
• W2183076943 cites W2103017472 @default.
• W2183076943 cites W2105944754 @default.
• W2183076943 cites W2106125553 @default.
• W2183076943 cites W2107598685 @default.
• W2183076943 cites W2108224203 @default.
• W2183076943 cites W2122883628 @default.
• W2183076943 cites W2125310307 @default.
• W2183076943 cites W2126226510 @default.
• W2183076943 cites W2134721852 @default.
• W2183076943 cites W2137785393 @default.
• W2183076943 cites W2145518651 @default.
• W2183076943 cites W2153996058 @default.
• W2183076943 cites W2157795344 @default.
• W2183076943 cites W2161834268 @default.
• W2183076943 cites W2161870241 @default.
• W2183076943 cites W2168063892 @default.
• W2183076943 cites W2168161193 @default.
• W2183076943 cites W2397929238 @default.
• W2183076943 cites W2582112616 @default.
• W2183076943 cites W397068069 @default.
• W2183076943 cites W2113240961 @default.
• W2183076943 cites W2132406583 @default.
• W2183076943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21409862" @default.
• W2183076943 hasPublicationYear "2011" @default.
• W2183076943 type Work @default.
• W2183076943 sameAs 2183076943 @default.
• W2183076943 citedByCount "3" @default.
• W2183076943 countsByYear W21830769432014 @default.
• W2183076943 countsByYear W21830769432020 @default.
• W2183076943 crossrefType "journal-article" @default.
• W2183076943 hasAuthorship W2183076943A5037518774 @default.
• W2183076943 hasAuthorship W2183076943A5060266030 @default.
• W2183076943 hasAuthorship W2183076943A5070114419 @default.
• W2183076943 hasAuthorship W2183076943A5070804361 @default.
• W2183076943 hasAuthorship W2183076943A5076238135 @default.
• W2183076943 hasAuthorship W2183076943A5078374399 @default.
• W2183076943 hasAuthorship W2183076943A5080895200 @default.
• W2183076943 hasConcept C104317684 @default.
• W2183076943 hasConcept C131872663 @default.
• W2183076943 hasConcept C150194340 @default.
• W2183076943 hasConcept C160798450 @default.
• W2183076943 hasConcept C16685009 @default.
• W2183076943 hasConcept C172680121 @default.
• W2183076943 hasConcept C187882448 @default.
• W2183076943 hasConcept C2776953305 @default.
• W2183076943 hasConcept C2779234561 @default.
• W2183076943 hasConcept C2781385326 @default.
• W2183076943 hasConcept C3019714739 @default.
• W2183076943 hasConcept C46973012 @default.
• W2183076943 hasConcept C54355233 @default.
• W2183076943 hasConcept C71924100 @default.
• W2183076943 hasConcept C86803240 @default.
• W2183076943 hasConceptScore W2183076943C104317684 @default.
• W2183076943 hasConceptScore W2183076943C131872663 @default.
• W2183076943 hasConceptScore W2183076943C150194340 @default.
• W2183076943 hasConceptScore W2183076943C160798450 @default.
• W2183076943 hasConceptScore W2183076943C16685009 @default.
• W2183076943 hasConceptScore W2183076943C172680121 @default.
• W2183076943 hasConceptScore W2183076943C187882448 @default.
• W2183076943 hasConceptScore W2183076943C2776953305 @default.
• W2183076943 hasConceptScore W2183076943C2779234561 @default.
• W2183076943 hasConceptScore W2183076943C2781385326 @default.
• W2183076943 hasConceptScore W2183076943C3019714739 @default.
• W2183076943 hasConceptScore W2183076943C46973012 @default.
• W2183076943 hasConceptScore W2183076943C54355233 @default.
• W2183076943 hasConceptScore W2183076943C71924100 @default.
• W2183076943 hasConceptScore W2183076943C86803240 @default.
• W2183076943 hasIssue "3" @default.
• W2183076943 hasLocation W21830769431 @default.
• W2183076943 hasOpenAccess W2183076943 @default.
• W2183076943 hasPrimaryLocation W21830769431 @default.

• next