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- W2183085210 abstract "OBJECTIVES: To (a) analyze recent evidence and research on adherence for human immunodeficiency virus (HIV) and hepatitis B treatment, including discussion on the dynamics and barriers of adherence, and (b) recommend strategies from the patient and clinician perspective to enhance patient adherence. SUMMARY: Since the widespread use of highly active antiretroviral therapy (HAART) for HIV infection, individuals with HIV are living much longer. A substantial percentage of individuals with HIV also have co-existing medical conditions, including co-infection with hepatitis viruses. While adherence to guidelines does not guarantee success or improved quality of life, 3 key factors affect treatment success: (1) drug resistance and cross-resistance, (2) adverse drug reactions and drug interactions, and (3) the level of adherence, which also affects resistance development. Adherence to treatment regimens remains 1 of the most important factors related to treatment success. Complete adherence to any medication regimen is difficult. In HIV disease, poor adherence is associated with development of resistance. Health care providers cannot predict patient adherence to therapy, but they can help patients overcome barriers to adherence and take their medication as directed. Simple regimens with once- or twice-daily dosing are preferred. The potential development of side effects depends on the individual patient. Treatment regimens must work with the patient’s lifestyle and schedule. Psychosocial issues are also very important. Patient belief that HAART is effective, and a positive relationship between patient and provider can promote adherence. Strategies to improve patient adherence can be grouped into 3 categories related to the patient: the clinic, the health-care team, and the regimen. Regimens should be simplified as much as possible: reducing the number of pills, their frequency, and dosing restrictions, as well as seeking to minimize drug interactions and side effects. The UCSF Positive Health Program Adherence Support Program is outlined. CONCLUSION: Adherence is an important aspect of HIV treatment. The key take-home message is that changing the antiretroviral therapy for a nonadherent patient is futile without addressing adherence barriers first." @default.
- W2183085210 created "2016-06-24" @default.
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- W2183085210 date "2008-01-01" @default.
- W2183085210 modified "2023-09-24" @default.
- W2183085210 title "Strategies to Enhance Adherence, Reduce Costs, and Improve Patient Quality of Life" @default.
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