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• W2183093257 abstract "Commercial tablets of Rosuvastatin Calcium exhibit unsatisfactory dissolution profiles and, consequent ly, problems of absorption and poor bioavailability. Rosuvastati n Calcium (RST), a poorly water-soluble 3-hydroxy3-methyl glut aryl CoA (HMG-CoA) Reductase inhibitor through inclusion complexation with hydroxy propyl β-cyclodextrin (HP-β-CD). The aim of this work was to develop Rosuvastatin Orodispersible tablets by exploiting the solubi lizing effect of hydroxy propyl β-cyclodextrin (HP-β-CD). Drug‐CD complex systems, prepared by different techniques, were characterized by differential scanning Calorim etry (DSC), X-ray diffractometry, and Fourier trans form infrared (FT-IR) spectroscopy. The inclusion complex containing RST: HP-β-CD (1:1) was formulated into tablets using superdisintegrants like sodium starch glycolate, Cr osspovidone and Crosscarmellose. Tablets containing RST-HPβ-CD inclusion complex were prepared by direct compression and evaluated for various post compression parameters like hardness, friability, weight variat ion, thickness, drug content and in-vitro dissoluti on. A significant improvement of the drug dissolution profile was ach ieved from tablets containing drug‐CD systems (Kneaded products showed the best dissolution profiles, reac hing more than 97.46% drug release in 20 min.). The stability of tablets was studied and no significant changes were detected in the dissolution profile of tablets after 1 month." @default.
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• W2183093257 date "2011-01-01" @default.
• W2183093257 modified "2023-09-27" @default.
• W2183093257 title "DEVELOPMENT AND EVALUATION OF ORODISPERSIBLE TABLETS OF ROSUVASTATIN CALCIUM -HP -β-CD INCLUSION COMPLEX BY USING DIFFERENT SUPERDISINTEGRANTS" @default.
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