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• W2183096358 startingPage "2761" @default.
• W2183096358 abstract "During development, muscles must form and attach at highly stereotyped positions to allow for coordinated movements. In Drosophila, muscles grow towards and attach to specifically positioned cells within the epidermis. At the molecular level, very little is known about how muscles recognize these attachment sites. The derailed gene encodes a receptor tyrosine kinase family member that is essential for the pathfinding ability of expressing neurons. Here we show that the Drl RTK is also expressed by a small subset of developing embryonic muscles and neighboring epidermal cells during muscle attachment site selection. In drl mutants, these muscles often fail to attach at appropriate locations although their epidermal attachment cells appear unaffected. These results show that, similar to its role in neuronal pathway recognition, the Drl RTK participates in a mechanism required for muscle attachment site selection. The data suggest that both neurons and muscles use common mechanisms to recognize their paths or targets, and that Drl plays an analogous role in both developing systems." @default.
• W2183096358 created "2016-06-24" @default.
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• W2183096358 date "1996-09-01" @default.
• W2183096358 modified "2023-09-26" @default.
• W2183096358 title "derailed is required for muscle attachment site selection in Drosophila" @default.
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• W2183096358 doi "https://doi.org/10.1242/dev.122.9.2761" @default.
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