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• W2183104443 endingPage "R1619" @default.
• W2183104443 startingPage "R1612" @default.
• W2183104443 abstract "Metallothionein (MT) is a sulfhydryl-rich protein involved mainly in heavy metal homeostasis and detoxification. In this study, the use of the mussel as an experimental model allowed us to test MT antioxidant properties at the molecular, cellular, and organism level. MT induction was achieved by mussel exposure to Cd (200 microg/l) in aquaria for 7 days followed by detoxification in the sea for 28 days. Cd-preexposed and nonexposed mussels were then treated with Fe (300-600 microg/l) in aquaria for 3 days. Biochemical assays on digestive gland tissue showed that treatment with Fe led to a significant increase in oxyradical production and malondialdehyde level only in mussels not preexposed to Cd. The Cd-dependent resistance to oxidative stress was ascribed to MT induction, as Cd produced no significant variation of reduced glutathione and major antioxidant enzymes. Digital imaging of isolated digestive gland cells showed lower oxyradical rise and higher viability in cells from Cd-preexposed mussels after treatments with 0.5-5 mM H2O2. Analyses on whole organisms showed that anoxic survival was lowered in mussels that had been treated with Fe, but such an effect was less pronounced in Cd-preexposed mussels compared with nonpreexposed ones. In conclusion, data suggest an antioxidant role for MT, which seems to occur through oxyradical scavenging and is able to protect both isolated cells and the entire organism from oxidative stress." @default.
• W2183104443 created "2016-06-24" @default.
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• W2183104443 date "1999-12-01" @default.
• W2183104443 modified "2023-10-11" @default.
• W2183104443 title "Role of metallothionein against oxidative stress in the mussel<i>Mytilus galloprovincialis</i>" @default.
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• W2183104443 doi "https://doi.org/10.1152/ajpregu.1999.277.6.r1612" @default.
• W2183104443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10600906" @default.
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