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- W2183126359 abstract "A high throughput and sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS) method has been developed and validated for the estimation of Phenobarbital in human plasma. Phenobarbital was extracted from human plasma using solid-phase extraction technique using Phenytoin Sodium as internal standard. A Beta basic 8 column provided chromatographic separation of analyses followed by detection with mass spectrometry. The mass transition ion-pair was followed as m/z 251.4 → 98.0 for Phenobarbital. The method involves a simple multiplexing, rapid solid-phase extraction, simple isocratic chromatography conditions and mass spectrometric detection which enable detection at sub-nanogram levels. The proposed method has been validated for a linear range of 5.5 – 10.3 ng/mL with correlation coefficient ≥0.99 79. The precision and accuracy were within 10% for intra-HPLC runs and inter-HPLC runs. The overall recoveries for Phenobarbital were 99.89%. Total MS run time was 4 min. The developed method was applied for the determination of pharmacokinetic parameters of Phenobarbital following a single oral administration of a 30 mg Phenobarbital tablet in human plasma." @default.
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- W2183126359 date "2012-01-01" @default.
- W2183126359 modified "2023-09-22" @default.
- W2183126359 title "BIO-ANALYTICAL METHOD DEVELOPMENT AND ITS VALIDATION FOR ESTIMATION OF PHENOBARBITAL IN HUMAN PLASMA USING LIQUID CHROMATOGRAPHY COUPLED WITH TANDEM MASS" @default.
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