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- W2183130617 abstract "Objective To investigate HIF-1 α gene expression in human breast cancer cells and the role of HIF-i in tumor metastasis and invasion. Methods Human breast cancer cell lines were cultured under normoxic or hypoxic conditions. Western blot was used to evaluate the protein expression of HIF-1α,p-vimentin and α-tubulin. Small interfering RNA targeting HIF-1α was used to block the expression of HIF1α in MDA-MB-231 and SK-BR-3 cell lines. Matrigel transwell and cell wound healing assays were used to detect the capability of cellular invasion and migration, respectively. Results Under normoxic condition,all the cell lines tested showed a base-level of HIF-1αt expression. The highest expression level of HIF-1αprotein was obtained in the MDA-MB-231 cell line, which is also noticed to be highly invasive and migratory in behavior. HIF-1α siRNA was capable of blocking the protein expression of both HIF-1α and p-vimentin and in addition, the attenuated ability of invasion and migration. Conclusion Since HIF-1 is able to promote invasion and metastasis of tumor cells, which may be considered as a target in anti-cancer therapy.Key words: Breast neoplasms; Neoplasm invasiveness; Neoplasm metastasis; RNAinterference; Vimentin; HIF-1α" @default.
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- W2183130617 date "2011-02-01" @default.
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- W2183130617 title "[Impact of hypoxia-inducible factor-1 on tumor invasion and metastasis in breast cancer]." @default.
- W2183130617 doi "https://doi.org/10.3760/cma.j.jssn.0529-5807.2011.02.007" @default.
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