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• W2183150785 abstract "Age-related macular degeneration (AMD) is the leading cause of vision loss in people over the age of 50 years in developed countries. The number of people affected is expected to increase over the next ten years because of the increase in the aging population. In recent years, a novel class of non-coding RNA, microRNA (miRNA), has emerged as an important regulator of numerous biological cell functions. Among these actions are the basic maintenance of cell signaling and metabolism. Disruption of physiological miRNA functions in retinal pigment epithelium cells can contribute to the development of the chronic atrophy observed in the early phases of AMD. Moreover, numerous studies indicate that miRNAs have a crucial role in regulating angiogenesis and vascular homeostasis; thus, miRNAs might play an important role in the choroid neovascularization typical of late AMD. The increasing relevance of miRNAs in retinal tissue has prompted investigations to evaluate their potential as therapeutic and diagnostic targets. In this review, we summarize the current findings on the potential involvement of miRNAs in AMD pathogenesis. We also review recent attempts to use miRNA to modulate biological cellular responses in retinal degeneration and we delineate new perspectives for applying miRNAs as new therapeutic targets and tools for therapeutic interventions." @default.
• W2183150785 created "2016-06-24" @default.
• W2183150785 creator A5014971780 @default.
• W2183150785 date "2014-01-01" @default.
• W2183150785 modified "2023-09-27" @default.
• W2183150785 title "The role of microRNA in the pathogenesis of age-related macular degeneration: its pathophysiology and potential pharmacological aspects" @default.
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• W2183150785 hasPublicationYear "2014" @default.
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