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• W2183207406 abstract "Aim: To study the clinical presentation of patients with Glanzmann's thrombasthenia (GT) and to correlate their clinical presentation and laboratory findings. Method: This is prospective study was carried out during the period 1stof January 2013 to end of December 2013 in the National Center of Hematology NCH, Baghdad/Iraq. Forty eight patients were enrolled in the study who were diagnosed as Glanzmann's thrombasthenia, medical history and clinical data were recorded, with the basic laboratory parameters includes: complete blood count (CBC), peripheral blood smear (PBS), prothrombin time(PT), activated partial thromoboplastin time (APTT), bleeding time (BT) and platelet aggregometry. Result: Forty eight patients were diagnosed in one year as GT, below 10 years were (68.75%), while below 20 years (79.16%), with male: female ratio 1.08:1. Regarding residency most of the patients were from Baghdad (39.58%), the second region was middle Euphrates (18.75%). From North of Iraq (16.66%), the last from the west and the east region each had equal percent (8.33%).Arabic patients were the majority (95.83%) and (4.16%) were Kurdish. The consanguineous marriages were noticed in most of the families (93.75%). Mucocutaneous bleedings were the most common type of bleeding which includes ecchymosis or petechiae then epistaxis followed by gum bleeding, menorrhagia was found in all females in the reproductive age group. The significant finding in laboratory test was prolonged bleeding time seen in (97.91%), platelet aggregation study was performed for all patients, all of them showed absent or impaired aggregation with ADP, collagen, and epinephrine while disaggregation with high dose of ristocetin except in one whodisplay normal aggregation pattern with high dose of ristocetin. Hence most of our patients presented with the classical symptoms and laboratory findings of GT however some had unusual findings. Conclusion: GT cannot be regarded as rare disease in Iraq, mostly seen in Arab ethnic group. Another study is recommended with longer time to identify the true incidence of GT in Iraq. Although basic hemostatic screening tests and platelet aggregometry are sufficient to diagnose the majority of patients, yet some may require more sophisticated tests like flow cytometry for glycoprotein (GP) IIb-IIIa and cytogenetic study." @default.
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• W2183207406 date "2015-01-01" @default.
• W2183207406 modified "2023-09-24" @default.
• W2183207406 title "Glanzmann's Thrombasthenia in Iraq" @default.
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