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- W2183208385 abstract "Advanced-age is associated with significant changes in physiological functions, absorption, distribution, metabolism and elimination of drugs. Antiarrhythmic drugs are traditionally classified into four groups, according to Vaughan Wil liams’s classification. The renal and hepatic elimination of many antiarrhythmic drug classes are reduced in the elderly, predisposing this population to serious adverse drug effects. Therapeutic drug monitoring has been a useful clinical tool in the safe use of class I drugs and amiodarone, in the younger population. Given the changes in pharmacokinetics of antiarrhythmic drugs and increased risk of adverse effects in older patients, therapeutic drug monitoring may be of particular importance for dosage adjustment and optimization of individual antiarrhythmic therapy in the elderly. [Life Science Journal. 2007; 4(2): 1 – 7] (ISSN: 1097 – 8135)." @default.
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- W2183208385 date "2007-01-01" @default.
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- W2183208385 title "Changes in pharmacokinetics in the elderly and therapeutic drug monitoring of antiarrhythmic drugs" @default.
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