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- W2183236105 abstract "The bioequivalence of metronidazole tablet 200mg reference (Flagyl®) and another brand of metronidazole 200mg (Brand AB) were compared in 6 healthy male volunteers. With mean aged of 23.5±2.0 years and mean body weight of 65.5± 4.5kg. A randomized cross-over design with two weeks wash-out period between each dose of 400mg oral dose was applied. Salivary sample before dosing and at various appropriate time interval of 15 mins, 30 mins, 1, 2, 3, 4, 5, 6 hours were analyzed by validated double beam U.V. spectrophotometer method, with 96.1% extraction recovery. Pharmacokinetic parameters for bioequivalence evaluation Cmax, Tmax and AUC were determined, the values of reference tablet. Flagyl® was Cmax 7.20 ±0.58μg/ml, Tmax 65.00 ±0.49mins and AUC0 6 69.50± 1.15μg/ml/hr. Brand AB (test) was Cmax 7.00 ± 0.43μg/ml, Tmax 70.00±0.41 mins and AUC0 6 65.50±0.89μg/ml/hr. The test Brand AB over reference ratios of the pharmacokinetic parameters obtained was found to be within bioequivalence acceptable range of 0.8 – 1.25, indicating (Brand AB) was bioequivalent to Flagyl ® (Innovator brand)." @default.
- W2183236105 created "2016-06-24" @default.
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- W2183236105 date "2007-01-01" @default.
- W2183236105 modified "2023-09-27" @default.
- W2183236105 title "BIOEQUIVALENCE EVALUATION OF TWO BRANDS OF METRONIDAZOLE TABLETS IN HEALTHY HUMAN VOLUNTEERS" @default.
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