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- W2183242557 abstract "A simple, accurate, precise and sensitive HPLC-UV method was developed for the determination of secnidazole in pharmaceutical formulations. This method developed and validated in the present study. The mobile phase consists of mixed buffer, Methanol and Acetonitrile in the ratio 60: 30: 10 and adjusts the p H to 6.8 with dilute sodium hydroxide solution. This was found to give a sharp peak of Secnidazole at a retention time of 2.705 min. HPLC analysis on column Ace, C8, 150 X 4.6, 5µ of Secnidazole was carried out at a wavelength of 254nm, with a flow rate of 1.0 ml min -1 linear regression analysis data for the Calibration curve showed a good linear relationship with regression coefficient 0.998 in the concentration range of 25 µg/ml -1 to 150 µg/ml -1 .The linear regression equation was Y=11361×- 9156.The developed method was employed with a high degree of precision and accuracy for the analysis of Secnidazole. The method was validated for accuracy, precision, robustness, detection and quantification limits as for ICH guidelines. The wide linearity range, accuracy, sensitivity, short retention time and composition of the mobile phase indicate that this method was successfully applied to quantification of Secnidazole." @default.
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- W2183242557 date "2014-01-01" @default.
- W2183242557 modified "2023-09-27" @default.
- W2183242557 title "VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF SECNIDAZOLE IN BULK AND ITS PHARMACEUTICAL DOSAGE FORMS" @default.
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