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- W2183243609 abstract "Amblyopia isaneuronal abnormality ofvi- sionthatisoften considered irreversible inadults. Wefound strong andsignificant improvement ofVernier acuity in humanadults withnaturally occurring amblyopia following practice. Learning wasstrongest atthetrained orientation anddidnottransfer toanuntrained task(detection), butit didtransfer partially totheuntrained eye(primarily atthe trained orientation). Weconclude thatthis perceptual learn- ingreflects alterations inearly neural processes thatare localized beyond thesite ofconvergence ofthetwoeyes. Our results suggest asignificant degree ofplasticity inthevisual system ofadults withamblyopia. Amblyopia isadevelopmental disorder that occurs during a period ofneural plasticity early inlife (1). Theconsequences ofamblyopia include areduced complement ofcortical neu- ronsthat canbedriven through theamblyopic eyeandreduced visual acuity (2,3).Generally, treatment ofamblyopia isonly undertaken ininfants andyoungchildren; however, recent studies suggest thatrepetitive practice canimprove perfor- manceonavariety ofvisual tasks inadult humans withnormal visual capacities. Theimprovement inperformance that fol- lowspractice maybequite specific tothelearned orientation (4-8), retinal location (5,7-11), spatial frequency (5,8), and direction ofmotion (12). Herewereport that adult amblyopes also demonstrate substantial andsignificant perceptual learn- ingofVernier acuity, andthat this learning reflects alterations inearly neural processes, perhaps duetosharpening ofneural responses (13), that aretask- andorientation-specific, butare" @default.
- W2183243609 created "2016-06-24" @default.
- W2183243609 creator A5034172250 @default.
- W2183243609 date "1996-01-01" @default.
- W2183243609 modified "2023-09-27" @default.
- W2183243609 title "Neuralplasticity inadults withamblyopia (Vernier acuity/learning/orientation/hyperacuity/practice)" @default.
- W2183243609 hasPublicationYear "1996" @default.
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