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- W2183252742 abstract "In the present study Bacopa monniera methanol extract (mBME) was evaluated against carbon tetrachloride induced hepatic and renal damage in rats. The in-vitro antioxidant activity of mBME was determined by DPPH free radical scavenging assay. Acute treatment with carbon tetrachloride (2 ml/kg) caused elevation of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and creatinine and induced histopathological changes as severe necrosis of centrilobular hepatocytes, microvesicular as well as macrovesicular steatosis in liver and tubular dilatation with epithelial cells necrosis and interstitial nephritis in kidneys. Pretreatment with mBME (40 mg/kg) for 14 days decreased the serum ALT, AST and creatinine levels and protected liver and kidneys from the toxicological influence of carbon tetrachloride. The EC50 for the DPPH free radical scavenging assay of mBME (19.20 μg/ml) as compared to ascorbic acid (4.510 μg/ml) and BHT (8.561 μg/ml) revealed that mBME had an efficient antioxidant potential. The protective effect of Bacopa monniera against carbon tetrachloride induced hepato-nephrotoxicity may be due to its strong antioxidant activity." @default.
- W2183252742 created "2016-06-24" @default.
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- W2183252742 date "2014-01-01" @default.
- W2183252742 modified "2023-09-27" @default.
- W2183252742 title "PROTECTIVE EFFECT OF BACOPA MONNIERA METHANOL EXTRACT AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY AND NEPHROTOXICITY" @default.
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