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- W2183282783 abstract "Immunization against poliomyelitis began in the fifties of the previous century, with the development of a formalin-inactivated poliovirus vaccine (IPV). Shortly later, a live attenuated oral poliovirus vaccine (OPV) was developed. It has been shown that both vaccines are very effective, but they achieve success in different ways. The virus causing the disease, i.e. poliovirus, has been and is still the most extensively studied virus in the world. In the eighties of the previous century, the complete genomes of several poliovirus strains have been sequenced and the capsid structure has been elucidated at the atomic level. These scientific break-throughs of modern molecular genetics and immunology have opened the way for the development for new or alternative vaccines. Consequently, different innovative approaches were undertaken to develop better vaccines, in order to improve the control of poliomyelitis. Some of these developments, such as the capsid stabilisation of the OPV and the use of subviral particles produced in yeast as an alternative vaccine, will be discussed. The eradication programme of WHO will be discussed with an open mind to questions such as: (1) Is eradication possible? (2) Which vaccine should be used for the eradication? (3) Can we ever stop poliovaccination? (4) What is the impact of bioterrorism on poliovaccination policy?" @default.
- W2183282783 created "2016-06-24" @default.
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- W2183282783 date "2005-01-01" @default.
- W2183282783 modified "2023-09-27" @default.
- W2183282783 title "History and future of poliovaccination, a personal account *" @default.
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- W2183282783 hasPublicationYear "2005" @default.
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