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- W2183399369 abstract "Islet amyloid polypeptides (IAPP) are coexpressed with insulin by pancreatic beta-cells. In abnormal conditions, amyloid deposits disrupt the structural integrity of beta-cell membranes, thus leading to a reduction/loss of beta-cells. In order to understan d the genetic basis of various diseases, especially polygenic diseases (diabetes, obesity and vascular disease), we made a rough analysis of INS gene from 11 species and IAPP gene from 9 species. For t his study we used some methods previously presented by authors, such as Kappa Index of Coincid ence (Kappa IC) patterns and in-depth analysis. Our results show some sequence features of these two genes that can not be detected by usual methods, such as sequence alignment. Although there is a high homology between insulin sequences, the proinsulin C-peptide differs between species. F rom an evolutionary standpoint, a comparison of these genes may lead to a better understanding of s ome diabetes-related mechanisms." @default.
- W2183399369 created "2016-06-24" @default.
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- W2183399369 date "2011-01-01" @default.
- W2183399369 modified "2023-10-15" @default.
- W2183399369 title "INSULIN AND ISLET AMYLOID POLYPEPTIDE GENES IN DIFFERENT SPECIES" @default.
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