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• W2183420004 abstract "The demand for a sustained-release MX delivery system for the treatment of rheumatoid arthritis is clear. This was the driving force for the study. The aim of this work was to utilize the biocompatibility characteristics of the biodegradable polymers viz. poly lactideco-glycolide (PLGA) and poly e-caprolactone (PCL) to prepare sustained release injectable microspheres of the anti-inflammatory drug Meloxicam (MX). MX microspheres were prepared using O/W emulsion-solvent evaporation/extraction method. The influence of the formulation parameters on the characteristics of the prepared microspheres was investigated to achieve formulation with suitable injectable size, high encapsulation efficiency, and sustained drug release with minimal burst release. Selected microspheres formulation was injected in an animal model to determine MX plasma level and compared with MX suspension. Results showed that microspheres prepared using PCL-PLGA blend showed improved sustained release pattern with lower initial burst. Formula F41 was selected the optimum formula, with 20% w/v PCL in PLGA and drug: polymer ration 1:2.5 and showed 72.3% of yield and encapsulation efficiency % (EE%) of 93.3 %. In Vivo studies showed that selected microspheres formula from polymer blend (formula F 41) when injected into rats showed therapeutic MX levels achieved for 21 successive days." @default.
• W2183420004 created "2016-06-24" @default.
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• W2183420004 date "2013-01-01" @default.
• W2183420004 modified "2023-09-26" @default.
• W2183420004 title "Meloxicam Depot Parenteral Bio-Degradable Microspheres: Preparation, Characterization and In-Vivo Evaluation" @default.
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• W2183420004 hasPublicationYear "2013" @default.
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