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• W2183432756 abstract "Background: Clerodendrum viscosum vent (verbenaceae) leaves and roots has been used as an antiseptic, anti inflammatory and antipyretic in Indian medical traditional system. The present study was designed to investigate the analgesic and anti inflammatory activity of ethanol extract of Clerodendrum viscosum root (EECVR). Coarse powders of Clerodendrum viscosum root was subjected to successive maceration process with petroleum ether, ethyl acetate, chloroform and ethanol. These extracts were subjected to phytochemical analysis. Estimation of total alkaloid was performed for EECVR using UV-Vis spectroscopy. Analgesic activity of EECVR was determined by hot plate, tail immersion, acetic acid induced writhing and formalin test. Anti-inflammatory activity of EECVR was investigated by carrageenan induced paw edema in Swiss albino mice. Phytochemical test showed presence of alkaloids in EECVR. Total alkaloid content was found to be 1.4 %w/w. The EECVR (at a dose 200 and 400 mg/kg) showed potent analgesic activity (p<0.001) against acetic acid induced writhing and delayed phase of formalin test when compared to tail immersion and tail flick method. This extract also exhibited significant (p<0.001) anti-inflammatory effect in carrageenan induced paw edema. In this study, EECVR (at a dose 200 and 400 mg/kg) showing appropriate anti-inflammatory and analgesic effect which may act through the cyclooxygenase enzyme system. Moreover, presence of alkaloid in EECVR may be the responsible for the potential anti-inflammatory and analgesic activity. © 2012 Universal Research Publications. All rights reserved" @default.
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• W2183432756 date "2012-01-01" @default.
• W2183432756 modified "2023-09-27" @default.
• W2183432756 title "ISSN: 2249-0353 Original Article Ethanol extract of Clerodendrum viscosum vent Roots: Investigation of analgesic and anti inflammatory effects in male adult Swiss albino mice." @default.
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