FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2183452457> ?p ?o ?g. }

• W2183452457 endingPage "13" @default.
• W2183452457 startingPage "3" @default.
• W2183452457 abstract "A number of investigators have suggested that exposure to low-dose radiation may pose a potentially serious health risk. However, the majority of these studies have focused on the short-term rather than long-term effects of exposure to fixed source radiation, and few have examined the effects of internal contamination. Additionally, very few studies have focused on exposure in juveniles, when organs are still developing and could be more sensitive to the toxic effects of radiation. To specifically address whether early-life radiation injury may affect long-term immune competence, we studied 14-day-old juvenile pups that were either 5 Gy total-body irradiated or injected internally with 50 μCi soluble (137)Cs, then infected with influenza A virus at 26 weeks after exposure. After influenza infection, all groups demonstrated immediate weight loss. We found that externally irradiated, infected animals failed to recover weight relative to age-matched infected controls, but internally (137)Cs contaminated and infected animals had a weight recovery with a similar rate and degree as controls. Externally and internally irradiated mice demonstrated reduced levels of club cell secretory protein (CCSP) message in their lungs after influenza infection. The externally irradiated group did not recover CCSP expression even at the two-week time point after infection. Although the antibody response and viral titers did not appear to be affected by either radiation modality, there was a slight increase in monocyte chemoattractant protein (MCP)-1 expression in the lungs of externally irradiated animals 14 days after influenza infection, with increased cellular infiltration present. Notably, an increase in the number of regulatory T cells was seen in the mediastinal lymph nodes of irradiated mice relative to uninfected mice. These data confirm the hypothesis that early-life irradiation may have long-term consequences on the immune system, leading to an altered antiviral response." @default.
• W2183452457 created "2016-06-24" @default.
• W2183452457 creator A5001702479 @default.
• W2183452457 creator A5003868236 @default.
• W2183452457 creator A5016357883 @default.
• W2183452457 creator A5039785140 @default.
• W2183452457 creator A5055627019 @default.
• W2183452457 creator A5066719132 @default.
• W2183452457 creator A5066804914 @default.
• W2183452457 creator A5074898787 @default.
• W2183452457 creator A5087989122 @default.
• W2183452457 creator A5088760586 @default.
• W2183452457 creator A5089732429 @default.
• W2183452457 date "2015-07-01" @default.
• W2183452457 modified "2023-10-17" @default.
• W2183452457 title "Examining the Effects of External or Internal Radiation Exposure of Juvenile Mice on Late Morbidity after Infection with Influenza A" @default.
• W2183452457 cites W1968613163 @default.
• W2183452457 cites W1982054904 @default.
• W2183452457 cites W2006181104 @default.
• W2183452457 cites W2009456296 @default.
• W2183452457 cites W2027954222 @default.
• W2183452457 cites W2030759937 @default.
• W2183452457 cites W2033870117 @default.
• W2183452457 cites W2038241292 @default.
• W2183452457 cites W2039202337 @default.
• W2183452457 cites W2046999269 @default.
• W2183452457 cites W2048984089 @default.
• W2183452457 cites W2049828276 @default.
• W2183452457 cites W2060259960 @default.
• W2183452457 cites W2062044533 @default.
• W2183452457 cites W2072737315 @default.
• W2183452457 cites W2077058058 @default.
• W2183452457 cites W2077300701 @default.
• W2183452457 cites W2077304810 @default.
• W2183452457 cites W2084578116 @default.
• W2183452457 cites W2086614037 @default.
• W2183452457 cites W2087514861 @default.
• W2183452457 cites W2103145789 @default.
• W2183452457 cites W2109068914 @default.
• W2183452457 cites W2118681350 @default.
• W2183452457 cites W2123625247 @default.
• W2183452457 cites W2129839992 @default.
• W2183452457 cites W2130927464 @default.
• W2183452457 cites W2131320161 @default.
• W2183452457 cites W2136047624 @default.
• W2183452457 cites W2146732012 @default.
• W2183452457 cites W2147892082 @default.
• W2183452457 cites W2148226248 @default.
• W2183452457 cites W2150871836 @default.
• W2183452457 cites W2156360019 @default.
• W2183452457 cites W2160216664 @default.
• W2183452457 cites W2164107793 @default.
• W2183452457 cites W249911154 @default.
• W2183452457 cites W4229603179 @default.
• W2183452457 doi "https://doi.org/10.1667/rr13917.1" @default.
• W2183452457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4516787" @default.
• W2183452457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26114328" @default.
• W2183452457 hasPublicationYear "2015" @default.
• W2183452457 type Work @default.
• W2183452457 sameAs 2183452457 @default.
• W2183452457 citedByCount "11" @default.
• W2183452457 countsByYear W21834524572016 @default.
• W2183452457 countsByYear W21834524572019 @default.
• W2183452457 countsByYear W21834524572020 @default.
• W2183452457 countsByYear W21834524572021 @default.
• W2183452457 countsByYear W21834524572022 @default.
• W2183452457 countsByYear W21834524572023 @default.
• W2183452457 crossrefType "journal-article" @default.
• W2183452457 hasAuthorship W2183452457A5001702479 @default.
• W2183452457 hasAuthorship W2183452457A5003868236 @default.
• W2183452457 hasAuthorship W2183452457A5016357883 @default.
• W2183452457 hasAuthorship W2183452457A5039785140 @default.
• W2183452457 hasAuthorship W2183452457A5055627019 @default.
• W2183452457 hasAuthorship W2183452457A5066719132 @default.
• W2183452457 hasAuthorship W2183452457A5066804914 @default.
• W2183452457 hasAuthorship W2183452457A5074898787 @default.
• W2183452457 hasAuthorship W2183452457A5087989122 @default.
• W2183452457 hasAuthorship W2183452457A5088760586 @default.
• W2183452457 hasAuthorship W2183452457A5089732429 @default.
• W2183452457 hasBestOaLocation W21834524572 @default.
• W2183452457 hasConcept C115961737 @default.
• W2183452457 hasConcept C16685009 @default.
• W2183452457 hasConcept C203014093 @default.
• W2183452457 hasConcept C2522874641 @default.
• W2183452457 hasConcept C2777546802 @default.
• W2183452457 hasConcept C2779341262 @default.
• W2183452457 hasConcept C2781184567 @default.
• W2183452457 hasConcept C42407357 @default.
• W2183452457 hasConcept C54355233 @default.
• W2183452457 hasConcept C71924100 @default.
• W2183452457 hasConcept C86803240 @default.
• W2183452457 hasConcept C8891405 @default.
• W2183452457 hasConceptScore W2183452457C115961737 @default.
• W2183452457 hasConceptScore W2183452457C16685009 @default.
• W2183452457 hasConceptScore W2183452457C203014093 @default.
• W2183452457 hasConceptScore W2183452457C2522874641 @default.
• W2183452457 hasConceptScore W2183452457C2777546802 @default.
• W2183452457 hasConceptScore W2183452457C2779341262 @default.

• next