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- W2183460143 abstract "L-Lysine has been shown to be indispensable for the growth of young rats (Osborne and Mendel, '15; Harris et al., '43; Wissler et al., '48; Kligler and Krehl, '50, '52) and for the maintenance of body weight in the adult rat (Wolf and Corley, '39; Neuberger and Webster, '45; Oillespie et al., '45). It also is necessary for the maintenance of normal weight in the dog (Rose and Rice, '39). Lysine deficiency causes a negative nitrogen balance in man within a few days (Albanese et al., '41). In 1943, Harris et al., reported cessation of growth, hypoproteinemia, atrophy of the subcutaneous fat and muscles and decrease in epiphyseal cartilage growth in young rats maintained on lysine-dA©ficient diets. It was demon strated by Kligler and Krehl ( '50, '52) that the lack of lysine prevented normal growth but allowed limited visceral and skeletal development, apparently at the expense of fat and carbohydrate reserves. In 1948,Fischer found that the omis sion of lysine from synthetic nutrient media resulted in di minished growth of osteoblasts in tissue cultures. In view of the fact that lysine is necessary for normal bone growth, the present study was undertaken to determine the effect of lysine deficiency on the healing of bone in the adult rat. EXPERIMENTAL One hundred and four young adult, male rats of the Sprague-Dawley strain, with an average weight of 232 gm," @default.
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- W2183460143 date "1955-11-01" @default.
- W2183460143 modified "2023-10-16" @default.
- W2183460143 title "Bone Healing in Lysine-Deficient Rats" @default.
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- W2183460143 doi "https://doi.org/10.1093/jn/57.3.305" @default.
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