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- W2183461568 abstract "It had been demonstrated that Glycyrrhiza glabra extract has biological capabilities include detoxication, antioxidation, and antiinfection properties, although there is little data about its probable side effects on the liver integrity. So, the effects of G. glabra administration on the livers histology and some biochemical parameters were investigated in the rats. Thirty-two Sprague-Dawley male rats were randomly distributed into four groups (n=8). Experimental groups were injected intra-peritoneal with aqueous extract of G. glabra at 50, 100 and 200 mg/kg/day, respectively, for 30 consecutive days while control group was injected with tap water without any add-on material. At the end of the experiments, tissue and blood samples were taken for histological evaluation and serum biochemical parameters assay, separately. The obtained results showed a decrease in diameter of hepatocytes and hepatocytes nuclear diameter and also an increase of sinusoids volume (P<0.05) in the liver of extract treated animals. Furthermore, hepatic necrosis, local mononuclear leukocyte infiltration and centrilobular hepatic congestion were observed in the liver of experimental animals. In addition, serum levels of ALP, AST and ALT showed a significant increase in 200 mg/kg extract received animals in comparison with control (P<0.05). These findings showed that G. glabra could cause harmful impacts on the liver integrity, so caution should be paid to popular consumption of this plant. The present histological will also need to" @default.
- W2183461568 created "2016-06-24" @default.
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- W2183461568 date "2013-01-01" @default.
- W2183461568 modified "2023-09-23" @default.
- W2183461568 title "Aqueous Extract of Glycyrrhiza glabrous can induce Biochemical and Histopathological disorders on the Liver of Rats" @default.
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