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• W2183479098 abstract "Simian virus 40 (SV40) contaminated the early poliovirus vaccines used throughout much of the world during the late 1950’s and early 1960’s. SV40 is oncogenic in rodents and can transform human cells in vitro. Most epidemiologic studies, however, have failed to detect increased risks of cancer among those exposed to SV40-contami nated poliovirus vaccines, even after more than 30 years of follow-up. In contrast, an increasing number of recent DNA hybridization studies have reported detection of SV40 genomic sequences in human tumors. The majority of these reports have involved ependymoma, choroid plexus tumors, osteosarcomas, and mesotheliomas. Not all investigations have detected SV40 in human tissues, though, and even among positive studies, several factors such as the low levels of virus found in tumors (< 1 genome copy per tumor cell), raise uncertainties regarding the possible role of SV40 in human cancers. This review article briefly summarizes the evidence for and against recent assertions that SV40 is a human tumor virus." @default.
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• W2183479098 date "2001-01-01" @default.
• W2183479098 modified "2023-09-24" @default.
• W2183479098 title "Simian Virus 40 (SV40) and Human Cancers" @default.
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