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• W2183485017 abstract "The aim of the present study was to determine the incidence and antimicrobial susceptibility patterns of the most common gram-negative bacteria (GNB) causing infections in the intensive care units (ICUs) of Makkah hospitals. In addition to evaluate the production of extended spectrum-β-lactamases (ESBL) in Klebsiella pneumoniae and Escherichia coli as well as metallo-β-lactamases (MBL) in Pseudomonas aeruginosa and Acinetobacter baumannii. A total of 509 gram-negative pathogens were isolated from clinical specimens of patients admitted ICUs of Makkah hospitals between September 2009 and March 2010. The specimens were microbiologically investigated by the routine methods, and antibiotic susceptibility was performed by using automated instruments. ESBLs and MBLs were determined according to Clinical and Laboratory Standards Institute (CLSI). The types of ESBLs and MBLs were detected by polymerase chain reaction. A. baumannii was the common bacteria (37%) isolated from ICUs, followed by P. aeruginosa (29.1%), K. pneumonia (22.8%) and E. coli (10.6%). P. aeruginosa and A. baumannii isolates were highly resistant towards the most antibiotic agents. ESBLs production was identified in 37.1% and 31.5% of K. pneumonia and E. coli isolates, respectively, and MBLs in 20.9% of P. aeruginosa and 68.6% of A. baumannii isolates. In conclusion, GNB cause several nosocomial infections in ICUs patients of Makkah hospitals with high resistant rate to antimicrobial agents." @default.
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• W2183485017 date "2012-01-01" @default.
• W2183485017 modified "2023-09-27" @default.
• W2183485017 title "Antimicrobial Resistance of Gram-Negative Bacilli Causing Infections in Intensive Care Units in Makkah Hospitals- Saudi Arabia" @default.
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