Matches in SemOpenAlex for { <https://semopenalex.org/work/W2183495699> ?p ?o ?g. }
- W2183495699 endingPage "42556" @default.
- W2183495699 startingPage "42541" @default.
- W2183495699 abstract "Fatal influenza outcomes result from a combination of rapid virus replication and collateral lung tissue damage caused by exaggerated pro-inflammatory host immune cell responses. There are few therapeutic agents that target both biological processes for the attenuation of influenza-induced lung pathology. We show that Saikosaponin A, a bioactive triterpene saponin with previouslyestablished anti-inflammatory effects, demonstrates both in vitro and in vivo anti-viral activity against influenza A virus infections. Saikosaponin A attenuated the replication of three different influenza A virus strains, including a highly pathogenic H5N1 strain, in human alveolar epithelial A549 cells. This anti-viral activity occurred through both downregulation of NF-κB signaling and caspase 3-dependent virus ribonucleoprotein nuclear export as demonstrated by NF-κB subunit p65 and influenza virus nucleoprotein nuclear translocation studies in influenza virus infected A549 cells. Critically, Saikosaponin A also attenuated viral replication, aberrant pro-inflammatory cytokine production and lung histopathology in the widely established H1N1 PR8 model of influenza A virus lethality in C57BL/6 mice. Flow cytometry studies of mouse bronchoalveolar lavage cells revealed that SSa exerted immunomodulatory effects through a selective attenuation of lung neutrophil and monocyte recruitment during the early peak of the innate immune response to PR8 infection. Altogether, our results indicate that Saikosaponin A possesses novel therapeutic potential for the treatment of pathological influenza virus infections." @default.
- W2183495699 created "2016-06-24" @default.
- W2183495699 creator A5014942240 @default.
- W2183495699 creator A5027919454 @default.
- W2183495699 creator A5030651502 @default.
- W2183495699 creator A5036769734 @default.
- W2183495699 creator A5039692056 @default.
- W2183495699 creator A5041675076 @default.
- W2183495699 creator A5041829308 @default.
- W2183495699 creator A5044653852 @default.
- W2183495699 creator A5056558563 @default.
- W2183495699 creator A5061918014 @default.
- W2183495699 creator A5069907810 @default.
- W2183495699 creator A5075518169 @default.
- W2183495699 creator A5088224328 @default.
- W2183495699 date "2015-12-02" @default.
- W2183495699 modified "2023-09-27" @default.
- W2183495699 title "Saikosaponin A inhibits influenza A virus replication and lung immunopathology" @default.
- W2183495699 cites W1650671157 @default.
- W2183495699 cites W1810265271 @default.
- W2183495699 cites W1854632697 @default.
- W2183495699 cites W1896313207 @default.
- W2183495699 cites W1932202918 @default.
- W2183495699 cites W1975857445 @default.
- W2183495699 cites W1977142289 @default.
- W2183495699 cites W1980296966 @default.
- W2183495699 cites W1984371849 @default.
- W2183495699 cites W1985661966 @default.
- W2183495699 cites W1988873958 @default.
- W2183495699 cites W1992307639 @default.
- W2183495699 cites W1994656760 @default.
- W2183495699 cites W1996311210 @default.
- W2183495699 cites W1997110757 @default.
- W2183495699 cites W1999177172 @default.
- W2183495699 cites W2016155378 @default.
- W2183495699 cites W2018080823 @default.
- W2183495699 cites W2019920909 @default.
- W2183495699 cites W2020018172 @default.
- W2183495699 cites W2029893000 @default.
- W2183495699 cites W2031997312 @default.
- W2183495699 cites W2032725983 @default.
- W2183495699 cites W2037730374 @default.
- W2183495699 cites W2040638887 @default.
- W2183495699 cites W2046550710 @default.
- W2183495699 cites W2046975355 @default.
- W2183495699 cites W2048502224 @default.
- W2183495699 cites W2051522745 @default.
- W2183495699 cites W2053737668 @default.
- W2183495699 cites W2058013480 @default.
- W2183495699 cites W2058144955 @default.
- W2183495699 cites W2058740609 @default.
- W2183495699 cites W2061600879 @default.
- W2183495699 cites W2069366587 @default.
- W2183495699 cites W2083944844 @default.
- W2183495699 cites W2084308247 @default.
- W2183495699 cites W2087668602 @default.
- W2183495699 cites W2096313549 @default.
- W2183495699 cites W2100862582 @default.
- W2183495699 cites W2102263282 @default.
- W2183495699 cites W2103293702 @default.
- W2183495699 cites W2105053798 @default.
- W2183495699 cites W2107480391 @default.
- W2183495699 cites W2111307294 @default.
- W2183495699 cites W2113909720 @default.
- W2183495699 cites W2122399224 @default.
- W2183495699 cites W2123566238 @default.
- W2183495699 cites W2129313145 @default.
- W2183495699 cites W2129339954 @default.
- W2183495699 cites W2142943804 @default.
- W2183495699 cites W2147552876 @default.
- W2183495699 cites W2149087734 @default.
- W2183495699 cites W2149935933 @default.
- W2183495699 cites W2151174475 @default.
- W2183495699 cites W2151892297 @default.
- W2183495699 cites W2156622984 @default.
- W2183495699 cites W2157052741 @default.
- W2183495699 cites W2157469282 @default.
- W2183495699 cites W2159470225 @default.
- W2183495699 cites W2165829386 @default.
- W2183495699 cites W2168805652 @default.
- W2183495699 cites W2269608764 @default.
- W2183495699 cites W2917714433 @default.
- W2183495699 cites W819098472 @default.
- W2183495699 doi "https://doi.org/10.18632/oncotarget.6448" @default.
- W2183495699 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4767451" @default.
- W2183495699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26637810" @default.
- W2183495699 hasPublicationYear "2015" @default.
- W2183495699 type Work @default.
- W2183495699 sameAs 2183495699 @default.
- W2183495699 citedByCount "40" @default.
- W2183495699 countsByYear W21834956992016 @default.
- W2183495699 countsByYear W21834956992017 @default.
- W2183495699 countsByYear W21834956992018 @default.
- W2183495699 countsByYear W21834956992019 @default.
- W2183495699 countsByYear W21834956992020 @default.
- W2183495699 countsByYear W21834956992021 @default.
- W2183495699 countsByYear W21834956992022 @default.
- W2183495699 countsByYear W21834956992023 @default.