FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2183519809> ?p ?o ?g. }

• W2183519809 endingPage "1031" @default.
• W2183519809 startingPage "1026" @default.
• W2183519809 abstract "Rats were fed powdered rat chow or a rat chow diet containing 5% cholestyramine or 5% cholestyramine with Mevinolin (112 mg/100 g food, 200 mg/kg body weight per day). The specific activity of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase was determined at different times during the diurnal cycle of the enzyme. Animals fed cholestyramine had higher specific activities of HMG-CoA reductase at all time points tested when compared to controls. The specific activity at the peak in the diurnal cycle was approximately 8-fold higher in cholestyramine-treated animals. Rats administered the cholestyramine-Mevinolin diet had higher specific activities of the enzyme than either cholestyramine-treated or control animals. In the cholestyramine-Mevinolin-treated animals the peak in the diurnal cycle was shifted to D-12 (12th hour of the dark cycle) and the specific activity at this point was approximately 133-fold greater than the basal (L-6) activity in control animals. Optimal conditions for immunotitration studies were determined such that valid conclusions could be drawn from these data. Based on immunotitration experiments, the increased hepatic HMG-CoA reductase activity in cholestyramine-treated animals resulted in part from a 3-fold activation of the enzyme, while the increased specific activity in the cholestyramine-Mevinolin-treated animals was due solely to increased enzyme mass. Hence the administration of Mevinolin blocked the activation of the enzyme induced by feeding cholestyramine alone. This was confirmed by purifying the enzyme to apparent homogeneity from cholestyramine-Mevinolin-treated animals; the specific activity of this enzyme was 4,000-7,700 nmol NADPH oxidized/min per mg protein. Cholestyramine-Mevinolin treatment affords a novel system for generating milligram quantities of rat hepatic HMG-CoA reductase.-Tanaka, R. D., P. A. Edwards, S. Lan, E. M. Knoppel, and A. M. Fogelman. The effect of cholestyramine and Mevinolin on the diurnal cycle of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase." @default.
• W2183519809 created "2016-06-24" @default.
• W2183519809 creator A5021690153 @default.
• W2183519809 creator A5040164343 @default.
• W2183519809 creator A5053652324 @default.
• W2183519809 creator A5082866305 @default.
• W2183519809 creator A5088041366 @default.
• W2183519809 date "1982-09-01" @default.
• W2183519809 modified "2023-10-17" @default.
• W2183519809 title "The effect of cholestyramine and Mevinolin on the diurnal cycle of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase" @default.
• W2183519809 cites W1500360994 @default.
• W2183519809 cites W1603091820 @default.
• W2183519809 cites W1628429170 @default.
• W2183519809 cites W1966196964 @default.
• W2183519809 cites W1980455986 @default.
• W2183519809 cites W2022961230 @default.
• W2183519809 cites W2023867538 @default.
• W2183519809 cites W2052156572 @default.
• W2183519809 cites W2089640559 @default.
• W2183519809 cites W2100837269 @default.
• W2183519809 cites W2105877460 @default.
• W2183519809 cites W2115408217 @default.
• W2183519809 cites W2125149319 @default.
• W2183519809 cites W2137848503 @default.
• W2183519809 cites W4293247451 @default.
• W2183519809 cites W52919052 @default.
• W2183519809 doi "https://doi.org/10.1016/s0022-2275(20)38075-5" @default.
• W2183519809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6923909" @default.
• W2183519809 hasPublicationYear "1982" @default.
• W2183519809 type Work @default.
• W2183519809 sameAs 2183519809 @default.
• W2183519809 citedByCount "62" @default.
• W2183519809 crossrefType "journal-article" @default.
• W2183519809 hasAuthorship W2183519809A5021690153 @default.
• W2183519809 hasAuthorship W2183519809A5040164343 @default.
• W2183519809 hasAuthorship W2183519809A5053652324 @default.
• W2183519809 hasAuthorship W2183519809A5082866305 @default.
• W2183519809 hasAuthorship W2183519809A5088041366 @default.
• W2183519809 hasBestOaLocation W21835198091 @default.
• W2183519809 hasConcept C104950815 @default.
• W2183519809 hasConcept C126322002 @default.
• W2183519809 hasConcept C134018914 @default.
• W2183519809 hasConcept C134651460 @default.
• W2183519809 hasConcept C181199279 @default.
• W2183519809 hasConcept C185592680 @default.
• W2183519809 hasConcept C2777320049 @default.
• W2183519809 hasConcept C2778163477 @default.
• W2183519809 hasConcept C2778697171 @default.
• W2183519809 hasConcept C2779123261 @default.
• W2183519809 hasConcept C55493867 @default.
• W2183519809 hasConcept C71924100 @default.
• W2183519809 hasConcept C86803240 @default.
• W2183519809 hasConcept C98274493 @default.
• W2183519809 hasConceptScore W2183519809C104950815 @default.
• W2183519809 hasConceptScore W2183519809C126322002 @default.
• W2183519809 hasConceptScore W2183519809C134018914 @default.
• W2183519809 hasConceptScore W2183519809C134651460 @default.
• W2183519809 hasConceptScore W2183519809C181199279 @default.
• W2183519809 hasConceptScore W2183519809C185592680 @default.
• W2183519809 hasConceptScore W2183519809C2777320049 @default.
• W2183519809 hasConceptScore W2183519809C2778163477 @default.
• W2183519809 hasConceptScore W2183519809C2778697171 @default.
• W2183519809 hasConceptScore W2183519809C2779123261 @default.
• W2183519809 hasConceptScore W2183519809C55493867 @default.
• W2183519809 hasConceptScore W2183519809C71924100 @default.
• W2183519809 hasConceptScore W2183519809C86803240 @default.
• W2183519809 hasConceptScore W2183519809C98274493 @default.
• W2183519809 hasIssue "7" @default.
• W2183519809 hasLocation W21835198091 @default.
• W2183519809 hasOpenAccess W2183519809 @default.
• W2183519809 hasPrimaryLocation W21835198091 @default.
• W2183519809 hasRelatedWork W1966834268 @default.
• W2183519809 hasRelatedWork W1974488610 @default.
• W2183519809 hasRelatedWork W1983549081 @default.
• W2183519809 hasRelatedWork W2057158122 @default.
• W2183519809 hasRelatedWork W2066208447 @default.
• W2183519809 hasRelatedWork W2078309101 @default.
• W2183519809 hasRelatedWork W2079114853 @default.
• W2183519809 hasRelatedWork W2089640559 @default.
• W2183519809 hasRelatedWork W2168843442 @default.
• W2183519809 hasRelatedWork W2395344363 @default.
• W2183519809 hasVolume "23" @default.
• W2183519809 isParatext "false" @default.
• W2183519809 isRetracted "false" @default.
• W2183519809 magId "2183519809" @default.
• W2183519809 workType "article" @default.