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- W2183569699 abstract "Four groups of male albino mice (Mus musculus) were subcutaneously injected with normal saline (0.9 % NaCl2) or peganum harmala alcoholic seed extract (75, 100, 150 mg/ kg) at twice/ weekly interval for one month period. Thereafter, animals were scarified and specimens from the kidneys and liver were examined under light microscope for structural changes. Repeated treatment with peganum harmala seeds alcoholic extract caused dose- related structural changes in the kindney and liver of treated groups. In the kidney, severe changes were observed following 150 mg/ kg dose that were manifested by hemorrhage in interstitial connective tissue and blood vessels of the medulla and cortex as well as degeneration and necrosis in the epithelial lining of kidney tubules., and shrinkage in the glomeruli with widening in Bowman’s capsule. Peganum harmala seeds alcoholic extract at 75 and 100 mg/ kg caused slight to moderate histological changes in the cortex and medulla manifested as degeneration and hypertrophy of tubular epithelial lining with widening of loop of Henle with signs of glomerulonephritis. In the liver, repeated treatment of peganum harmala seeds alcoholic extract at 150 mg/ kg dose caused severe destruction of hepatic cells, pyknotic of hepatic cell nuclei and vesiculation in the cytoplasm due to fatty degeneration. In addition, widening in hepatic sinusoids and destruction in the walls of central veins were observed. Nuclear polymorph cellular infiltration and cirrhosis as well as widening in hepatic sinusoids and pyknotic in hepatic cell nuclei were noticed in the 100 mg/ kg dose group." @default.
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- W2183569699 date "2013-01-01" @default.
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- W2183569699 title "Effect of repeated administration of Peganum harmala alcoholic extract on the liver and kidney in Albino mice: A histo-pathological study" @default.
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