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- W2183569803 abstract "The methylenedioxy unit, present in Safrole synthon, can be identified in the clinical antitumour agents, as etoposide and teniposide. Safrole is metabolically activated to electrophilic intermediates that bind to cellular DNA. The DNA-binding properties from safrole, can be explored in drug design for obtain bioactive compounds, as antitumour and antiinflammatory agents. In view to obtain more selective and less toxic drugs, research is often directed to exploit latentiation of bioactive compounds, as approaches using small peptides or amino acids residues. As part of a research program aiming synthesis and pharmacological evaluation of novel possible antitumour prototype compounds, we describe here the in vitro antitumour activity of peptidyl-like derivatives containing the 1,3benzodioxole system. The nitro group in six position of 1,3-benzodioxole system, was added in this series. We suppose that these group could act to form reactive oxygen species (citotoxic to tumour cell) and as internal cathalizator, to chemical breakdown of the peptidyl-residues, activating the latent form these compounds." @default.
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- W2183569803 date "2004-01-01" @default.
- W2183569803 modified "2023-09-27" @default.
- W2183569803 title "Evaluation of the antitumour activity of peptidyl -like derivatives containing the 1,3-benzodioxole system" @default.
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