Matches in SemOpenAlex for { <https://semopenalex.org/work/W2183610572> ?p ?o ?g. }
- W2183610572 endingPage "1793" @default.
- W2183610572 startingPage "1785" @default.
- W2183610572 abstract "The maternal Dorsal nuclear gradient initiates the differentiation of the mesoderm, neurogenic ectoderm and dorsal ectoderm in the precellular Drosophila embryo. Each tissue is subsequently subdivided into multiple cell types during gastrulation. We have investigated the formation of the mesectoderm within the ventral-most region of the neurogenic ectoderm. Previous studies suggest that the Dorsal gradient works in concert with Notch signaling to specify the mesectoderm through the activation of the regulatory gene sim within single lines of cells that straddle the presumptive mesoderm. This model was confirmed by misexpressing a constitutively activated form of the Notch receptor, NotchIC, in transgenic embryos using the eve stripe2 enhancer. The NotchIC stripe induces ectopic expression of sim in the neurogenic ectoderm where there are low levels of the Dorsal gradient. sim is not activated in the ventral mesoderm, due to inhibition by the localized zinc-finger Snail repressor, which is selectively expressed in the ventral mesoderm. Additional studies suggest that the Snail repressor can also stimulate Notch signaling. A stripe2-snail transgene appears to induce Notch signaling in ‘naïve’ embryos that contain low uniform levels of Dorsal. We suggest that these dual activities of Snail, repression of Notch target genes and stimulation of Notch signaling, help define precise lines of sim expression within the neurogenic ectoderm." @default.
- W2183610572 created "2016-06-24" @default.
- W2183610572 creator A5049432621 @default.
- W2183610572 creator A5054520990 @default.
- W2183610572 date "2002-04-01" @default.
- W2183610572 modified "2023-10-16" @default.
- W2183610572 title "The Snail repressor positions Notch signaling in the<i>Drosophila</i>embryo" @default.
- W2183610572 cites W1859191570 @default.
- W2183610572 cites W1968993907 @default.
- W2183610572 cites W1974600364 @default.
- W2183610572 cites W1977084276 @default.
- W2183610572 cites W1990045619 @default.
- W2183610572 cites W1995724123 @default.
- W2183610572 cites W1996775753 @default.
- W2183610572 cites W2000550532 @default.
- W2183610572 cites W2006535640 @default.
- W2183610572 cites W2008076522 @default.
- W2183610572 cites W2016593419 @default.
- W2183610572 cites W2017133589 @default.
- W2183610572 cites W2023205404 @default.
- W2183610572 cites W2027128159 @default.
- W2183610572 cites W2037607587 @default.
- W2183610572 cites W2039009882 @default.
- W2183610572 cites W2041728327 @default.
- W2183610572 cites W2050867644 @default.
- W2183610572 cites W2055064474 @default.
- W2183610572 cites W2069878493 @default.
- W2183610572 cites W2072001338 @default.
- W2183610572 cites W2083280774 @default.
- W2183610572 cites W2083713766 @default.
- W2183610572 cites W2091513322 @default.
- W2183610572 cites W2095666604 @default.
- W2183610572 cites W2096969461 @default.
- W2183610572 cites W2099278290 @default.
- W2183610572 cites W2107326083 @default.
- W2183610572 cites W2114927646 @default.
- W2183610572 cites W2124220437 @default.
- W2183610572 cites W2131232165 @default.
- W2183610572 cites W2133616332 @default.
- W2183610572 cites W2144868620 @default.
- W2183610572 cites W2151240250 @default.
- W2183610572 cites W2151543050 @default.
- W2183610572 cites W2153395073 @default.
- W2183610572 cites W2154861644 @default.
- W2183610572 cites W2155608649 @default.
- W2183610572 cites W2167721895 @default.
- W2183610572 cites W2181352214 @default.
- W2183610572 cites W2188357884 @default.
- W2183610572 cites W2288761659 @default.
- W2183610572 cites W2392603828 @default.
- W2183610572 doi "https://doi.org/10.1242/dev.129.7.1785" @default.
- W2183610572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11923213" @default.
- W2183610572 hasPublicationYear "2002" @default.
- W2183610572 type Work @default.
- W2183610572 sameAs 2183610572 @default.
- W2183610572 citedByCount "57" @default.
- W2183610572 countsByYear W21836105722012 @default.
- W2183610572 countsByYear W21836105722013 @default.
- W2183610572 countsByYear W21836105722014 @default.
- W2183610572 countsByYear W21836105722016 @default.
- W2183610572 countsByYear W21836105722017 @default.
- W2183610572 countsByYear W21836105722018 @default.
- W2183610572 countsByYear W21836105722019 @default.
- W2183610572 countsByYear W21836105722020 @default.
- W2183610572 countsByYear W21836105722021 @default.
- W2183610572 countsByYear W21836105722022 @default.
- W2183610572 countsByYear W21836105722023 @default.
- W2183610572 crossrefType "journal-article" @default.
- W2183610572 hasAuthorship W2183610572A5049432621 @default.
- W2183610572 hasAuthorship W2183610572A5054520990 @default.
- W2183610572 hasConcept C104317684 @default.
- W2183610572 hasConcept C105702510 @default.
- W2183610572 hasConcept C129536746 @default.
- W2183610572 hasConcept C135073763 @default.
- W2183610572 hasConcept C145103041 @default.
- W2183610572 hasConcept C148738053 @default.
- W2183610572 hasConcept C161879069 @default.
- W2183610572 hasConcept C18903297 @default.
- W2183610572 hasConcept C196843134 @default.
- W2183610572 hasConcept C2777164004 @default.
- W2183610572 hasConcept C2779329299 @default.
- W2183610572 hasConcept C2779965526 @default.
- W2183610572 hasConcept C2780915607 @default.
- W2183610572 hasConcept C54355233 @default.
- W2183610572 hasConcept C62478195 @default.
- W2183610572 hasConcept C86803240 @default.
- W2183610572 hasConcept C87073359 @default.
- W2183610572 hasConcept C95444343 @default.
- W2183610572 hasConceptScore W2183610572C104317684 @default.
- W2183610572 hasConceptScore W2183610572C105702510 @default.
- W2183610572 hasConceptScore W2183610572C129536746 @default.
- W2183610572 hasConceptScore W2183610572C135073763 @default.
- W2183610572 hasConceptScore W2183610572C145103041 @default.
- W2183610572 hasConceptScore W2183610572C148738053 @default.
- W2183610572 hasConceptScore W2183610572C161879069 @default.
- W2183610572 hasConceptScore W2183610572C18903297 @default.
- W2183610572 hasConceptScore W2183610572C196843134 @default.
- W2183610572 hasConceptScore W2183610572C2777164004 @default.