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- W2183611041 abstract "Subjects in the control group received general oral and written information about diet and exercise at baseline and at annual visits. Laboratory and nursing staff were blinded to the patient assignments, but staff members involved in counselling and exercise programs were not. Data were analyzed using an intention-totreat principle. Results: The subjects were middleaged (mean 55 years) and obese (mean body mass index 31.2), with a mean fasting plasma glucose level of 6.1 mmol/L and a mean 2-hour postchallenge glucose level of 8.9 mmol/L. The subjects were followed for a mean of 3.2 years. Of the 86 new cases of diabetes diagnosed during follow-up, only 27 occurred in the intervention group. The cumulative incidence of diabetes at 4 years was 11% in the intervention group and 23% in the control group. Cox regression analysis showed that the cumulative incidence of diabetes was 58% lower in the intervention group than in the control group (hazard ratio 0.4; 95% confidence interval 0.3–0.7). Weight, waist circumference, plasma glucose and insulin levels 2 hours after the glucose challenge, and triglyceride levels were all significantly lower in the intervention group than in the control group. A lifestyle change “success score” of 0 to 5 was calculated for all subjects (5 representing the greatest success), and there was a strong inverse correlation between this score and the development of diabetes." @default.
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- W2183611041 date "2001-01-01" @default.
- W2183611041 modified "2023-09-27" @default.
- W2183611041 title "Lifestyle changes can prevent the development of diabetes mellitus" @default.
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