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- W2183611724 abstract "Pycnoporus sanguineus is a parasitic fungus found on dead broadleaf trees and used as a nutraceuticals and functional food. LPS-induced NO production in a mouse microglial cell line, BV-2 cells was used as inflammatory model to screen neuro-protective compounds from the cultivated mycelia of P. sanguineus. Bioassay-guided fractionation was led to the isolation of four ergostane skeleton type steroids, including ergosta-7,22-dien-3β-ol (1), 3β,5α-dihydroxyergosta-7,22-dien-6-one (2), 3β,5α,9α-trihydroxy-ergosta-7,22-dien-6-one (3), and 3β,5α,6α-trihydroxy-ergosta-7,22-diene (4) from mycelia of cultivated P. sanguineus. Among that, compounds 2, 3, and 4 were newly isolated in this species. Compound 1 showed significantly inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 cells, at a concentration of 15 μM in the value of 43.5%." @default.
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- W2183611724 date "2010-12-01" @default.
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- W2183611724 title "Anti-Inflammatory Principles of Cultivated Pycnoporus Sanguineus" @default.
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- W2183611724 doi "https://doi.org/10.6940/jcm.201012_21(3_4).01" @default.
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