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- W2183613085 abstract "TheBapolipoproteins, apo-B48 andapo-B100, arekeystructural proteins inthose classes oflipoproteins considered tobe atherogenic [e.g., chylomicron remnants, ,f-VLDL, LDL,oxidized LDL,andLp(a)J. Herewedescribe thedevelopment of transgenic miceexpressing highlevels ofhumanapo-B48 and apo-B100. A 79.5-kb humangenomic DNA fragment containingtheentire humanapo-Bgenewasisolated fromaP1bacteriophage library andmicroinjected into fertilized mouseeggs. 16transgenic founders expressing humanapo-Bweregenerated, andtheanimals withthehighest expression hadplasma apo-B100 levels nearly ashigh asthose ofnormolipidemic humans(-50mg/dl). Thehumanapo-B100 intransgenic mouseplasma waspresent largely inlipoproteins oftheLDL class asshownbyagarose gelelectrophoresis, chromatography onaSuperose 6column, anddensity gradient ultracentrifugation. Whenthehumanapo-B transgenic founders werecrossed withtransgenic miceexpressing humanapo(a), theoffspring that expressed bothtransgenes hadhigh plasma levels ofhumanLp(a). Boththehumanapo-B andLp(a) transgenic mice will bevaluable resources forstudying apo-Bmetabolism and therole ofapo-B andLp(a) inatherosclerosis. (J.Clin. Invest. 1993. 92:3029-3037.) Keywords: P1bacteriophage -lowdensity lipoproteins *cholesterol" @default.
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- W2183613085 date "1993-01-01" @default.
- W2183613085 modified "2023-09-27" @default.
- W2183613085 title "Transgenic MiceExpressing HighPlasmaConcentrations ofHumanApolipoprotein B100andLipoprotein(a)" @default.
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