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- W2183614403 abstract "It is well known that antagonists of N-type voltage-gated calcium channels inhibit the evoked quantal release of acetylcholine in amphibian neuromuscular synapses. This, however, does not exclude the functional expression of other types of voltage-gated calcium channels in these nerve terminals. Using immunocytochemistry, we detected the expression of the 1A subunit of P/Q-type calcium channels (that is otherwise typical of mammalian motor nerve endings) in the frog neuromuscular junction. In addition, we demonstrated that the P/Q-type channel blocker ω-agatoxin IVA (20 nM) reduced the action potential-induced calcium transient and significantly decreased both spontaneous and evoked mediator release. Our data indicates the functional expression of P/Q-type calcium channels in the frog motor nerve ending which participate in acetylcholine release." @default.
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- W2183614403 date "2011-10-17" @default.
- W2183614403 modified "2023-10-14" @default.
- W2183614403 title "Voltage-Dependent P/Q-Type Calcium Channels at the Frog Neuromuscular Junction" @default.
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- W2183614403 doi "https://doi.org/10.33549/physiolres.932219" @default.
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