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- W2183615122 endingPage "143" @default.
- W2183615122 startingPage "125" @default.
- W2183615122 abstract "Abstract Cytochrome P450 oxidoreductase (POR) is an enzyme that is essential for multiple metabolic processes; chiefly among them are reactions catalyzed by cytochrome P450 proteins for metabolism of steroid hormones, drugs, and xenobiotics. Mutations in POR cause a complex set of disorders that often resemble defects in steroid metabolizing enzymes 17-hydroxylase, 21-hydroxylase, and aromatase. Since the initial reports of POR mutations in 2004, more than 70 different mutations and polymorphisms in the POR gene have been identified and tested for their effect on activities of several steroid and drug metabolizing P450 proteins. Mutations in POR may have variable effects on different P450 partner proteins depending on the location of the mutation. The POR mutations that disrupt the binding of cofactors have a negative impact on all partner proteins, while mutations causing subtle structural changes may lead to altered interaction with partner proteins and the overall effect may be different for each partner." @default.
- W2183615122 created "2016-06-24" @default.
- W2183615122 creator A5024262855 @default.
- W2183615122 creator A5077460315 @default.
- W2183615122 date "2013-01-01" @default.
- W2183615122 modified "2023-09-26" @default.
- W2183615122 title "P450 Oxidoreductase Deficiency (PORD)" @default.
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