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- W2183616482 abstract "Objective: To develop simple, rapid UV spectrophotometric method for simultaneous determination of Pyridoxine hydrochloride (PYR) and Doxylamine succinate (DOX) in bulk and tablet dosage form by simultaneous equation method. Methods: Solubility studies were carried out to identify a suitable solvent for dissolving both PYR and DOX. Next, both drugs were dissolved individually as well as in combination in the solvent and their λmax values as well as absorption pattern over the wavelength 200 to 400 nm were studied. The data obtained was used to derive simultaneous equations for determining the concentrations of the two drugs. Different parameters of study were optimized and the method was validated as per ICH guidelines. Results: PYR and DOX showed absorption maxima at 290 and 260 nm respectively. They also showed significant absorption at each other’s maxima. Standard curves of both drugs obeyed Beer- Lamberts law in concentration range of 4-20 µg/ml. Simultaneous equations were developed and validated as per ICH guidelines for accuracy, linearity and precision. Marketed sample of tablets was analyzed by using the validated method and yielded accurate results. Conclusion: The method was found to be simple, accurate, precise, reproducible, economic and suitable for routine quality control analysis as well as validation of in-process parameters." @default.
- W2183616482 created "2016-06-24" @default.
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- W2183616482 date "2013-01-01" @default.
- W2183616482 modified "2023-09-24" @default.
- W2183616482 title "DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF DOXYLAMINE SUCCINATE AND PYRIDOXINE HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM" @default.
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