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- W2183617299 abstract "Multi-particulate drug delivery systems have shown several advantages over single unit ones, such as more uniform transit times through the gastro-intestinal tract, less variability among individuals and a smaller risk of dose dumping and high local concentrations. Polymers blends are widely studied to obtain controlled drug delivery systems, with designed characteristics. Polymer blend formulations can improve mechanical properties, reduce drug toxicity and control drug delivery (1). Widely used to prepare colonic delivery tablets, methacrylates and cellulose derivatives can be blended to obtain microparticles with this exact characteristic, using aqueous solutions. Eudragit S100 (EUD) [methacrylic acid methyl methacrylate copolymer (1:2)] is an enteric polymer that dissolves in aqueous solution presenting pH higher than 7. Hydroxypropylmethylcellulose (HPMC) is a hydrophilic derivative of cellulose that swells in presence of water. Pantoprazole sodium sesquihydrate (PAN), is a prodrug, protonated in acid medium of stomach parietal cells that binds irreversibly the H/KATPase. It is used in the treatment of digestive ulcers, gastro-esophageal reflux disease and Helicobacter pylori infections (2). This drug should only be activated inside gastric parietal cells. Therefore, it must be formulated in enteric drug delivery systems. The purpose of this study was to stabilize the pantoprazole in gastric acid medium by means of preparing controlled release microparticles, using Eudragit S100 and Methocel F4M blend." @default.
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- W2183617299 date "2005-01-01" @default.
- W2183617299 modified "2023-09-24" @default.
- W2183617299 title "PANTOPRAZOLE SODIUM-LOADED CONTROLLED RELEASE MICROPARTICLES PREPARED BY SPRAY DRYING" @default.
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