Matches in SemOpenAlex for { <https://semopenalex.org/work/W2183617376> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2183617376 endingPage "34" @default.
- W2183617376 startingPage "15" @default.
- W2183617376 abstract "Human chorionic gonadotropin (hCG) is a glycoprotein composed of two dissimilar subunits, α- and β-subunit, held together by charge interactions. hCG is produced by trophoblastic cells of the placenta in both pregnancy and gestational trophoblastic diseases. It is a remarkable glycoprotein in that up to 35% of the molecular weight (MW) is from oligosaccharide side chains. hCG is sometimes considered a mucopolysaccharide, like collagen, because of the large carbohydrate component. There is wide variation in hCG structure throughout normal and abnormal pregnancies, and in gestational trophoblastic diseases. In addition to “regular” hCG (hCG with intact subunits and the midtrimester pregnancy-like complement of oligosaccharides), at least six other key variants are present in serum samples: hyperglycosylated hCG, nicked hCG, hCG missing the β-subunit C-terminal peptide, free β-subunit, hyperglycosylated free β-subunit, and nicked free β-subunit as well as multiple combinations of these variants (i.e., nicked hyperglycosylated hCG missing the β-subunit C-terminal peptide). The same seven molecules plus the β-core fragment can be detected in urine samples (1–9). Table 1 and Fig. 1 summarize the structures of these key hCG-related molecules, which vary in size from β-core fragment (MW 9000–10,000) to hyperglycosylated hCG (MW 38,00042,000). hCG and related molecules may vary widely in charge because of differences in sialic acid content. As shown in Fig. 2, multiple charge isoforms in the range pI 3–7 are found in serum and urine samples, and in the range of pI 3–8 in hyperglycosylated hCG." @default.
- W2183617376 created "2016-06-24" @default.
- W2183617376 creator A5059355586 @default.
- W2183617376 date "2004-01-01" @default.
- W2183617376 modified "2023-09-27" @default.
- W2183617376 title "Human Chorionic Gonadotropin" @default.
- W2183617376 cites W1903066579 @default.
- W2183617376 cites W1916998316 @default.
- W2183617376 cites W1926822185 @default.
- W2183617376 cites W1952327476 @default.
- W2183617376 cites W1965773879 @default.
- W2183617376 cites W1969918461 @default.
- W2183617376 cites W1985339540 @default.
- W2183617376 cites W2010773526 @default.
- W2183617376 cites W2043239243 @default.
- W2183617376 cites W204465126 @default.
- W2183617376 cites W2050971119 @default.
- W2183617376 cites W2053141742 @default.
- W2183617376 cites W2061346814 @default.
- W2183617376 cites W2064143957 @default.
- W2183617376 cites W2067993963 @default.
- W2183617376 cites W2095260045 @default.
- W2183617376 cites W2095875015 @default.
- W2183617376 cites W2096400482 @default.
- W2183617376 cites W2103481478 @default.
- W2183617376 cites W2107484376 @default.
- W2183617376 cites W2123802026 @default.
- W2183617376 cites W2129568079 @default.
- W2183617376 cites W2155681941 @default.
- W2183617376 cites W2162464833 @default.
- W2183617376 cites W2171902197 @default.
- W2183617376 cites W2313571935 @default.
- W2183617376 cites W2322561651 @default.
- W2183617376 cites W4245898507 @default.
- W2183617376 cites W4302499444 @default.
- W2183617376 doi "https://doi.org/10.1007/978-1-59259-787-1_2" @default.
- W2183617376 hasPublicationYear "2004" @default.
- W2183617376 type Work @default.
- W2183617376 sameAs 2183617376 @default.
- W2183617376 citedByCount "0" @default.
- W2183617376 crossrefType "book-chapter" @default.
- W2183617376 hasAuthorship W2183617376A5059355586 @default.
- W2183617376 hasConcept C104292427 @default.
- W2183617376 hasConcept C104317684 @default.
- W2183617376 hasConcept C108625454 @default.
- W2183617376 hasConcept C126322002 @default.
- W2183617376 hasConcept C134018914 @default.
- W2183617376 hasConcept C172680121 @default.
- W2183617376 hasConcept C185592680 @default.
- W2183617376 hasConcept C2775948956 @default.
- W2183617376 hasConcept C2776953305 @default.
- W2183617376 hasConcept C2779234561 @default.
- W2183617376 hasConcept C2779281246 @default.
- W2183617376 hasConcept C2780115458 @default.
- W2183617376 hasConcept C54355233 @default.
- W2183617376 hasConcept C55493867 @default.
- W2183617376 hasConcept C71315377 @default.
- W2183617376 hasConcept C71924100 @default.
- W2183617376 hasConcept C86803240 @default.
- W2183617376 hasConceptScore W2183617376C104292427 @default.
- W2183617376 hasConceptScore W2183617376C104317684 @default.
- W2183617376 hasConceptScore W2183617376C108625454 @default.
- W2183617376 hasConceptScore W2183617376C126322002 @default.
- W2183617376 hasConceptScore W2183617376C134018914 @default.
- W2183617376 hasConceptScore W2183617376C172680121 @default.
- W2183617376 hasConceptScore W2183617376C185592680 @default.
- W2183617376 hasConceptScore W2183617376C2775948956 @default.
- W2183617376 hasConceptScore W2183617376C2776953305 @default.
- W2183617376 hasConceptScore W2183617376C2779234561 @default.
- W2183617376 hasConceptScore W2183617376C2779281246 @default.
- W2183617376 hasConceptScore W2183617376C2780115458 @default.
- W2183617376 hasConceptScore W2183617376C54355233 @default.
- W2183617376 hasConceptScore W2183617376C55493867 @default.
- W2183617376 hasConceptScore W2183617376C71315377 @default.
- W2183617376 hasConceptScore W2183617376C71924100 @default.
- W2183617376 hasConceptScore W2183617376C86803240 @default.
- W2183617376 hasLocation W21836173761 @default.
- W2183617376 hasOpenAccess W2183617376 @default.
- W2183617376 hasPrimaryLocation W21836173761 @default.
- W2183617376 hasRelatedWork W1967619051 @default.
- W2183617376 hasRelatedWork W1974368836 @default.
- W2183617376 hasRelatedWork W1995420981 @default.
- W2183617376 hasRelatedWork W2011782404 @default.
- W2183617376 hasRelatedWork W2018249696 @default.
- W2183617376 hasRelatedWork W2024151106 @default.
- W2183617376 hasRelatedWork W2067533280 @default.
- W2183617376 hasRelatedWork W2067878402 @default.
- W2183617376 hasRelatedWork W2099734673 @default.
- W2183617376 hasRelatedWork W2145510864 @default.
- W2183617376 isParatext "false" @default.
- W2183617376 isRetracted "false" @default.
- W2183617376 magId "2183617376" @default.
- W2183617376 workType "book-chapter" @default.